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Meta-Analysis
. 2022 Oct 10;62(1):35.
doi: 10.1186/s42358-022-00267-y.

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic)

Virginia Fernandes Moça Trevisani  1   2 , Aysa César Pinheiro  3 , Sonia Cristina de Magalhães Souza Fialho  4 , Marilena Leal Mesquita Silvestre Fernandes  5 , Alisson Pugliesi  6 , Sandra Gofinet Pasoto  7 , Maria Lucia Lemos Lopes  8 , Lissiane Karine Noronha Guedes  7 , Samira Tatiyama Miyamoto  9 , Laura Caldas Dos Santos  10 , Simone Appenzeller  6 , Tania Fidelix  10 , Sandra Lúcia Euzébio Ribeiro  11 , Danielle Christinne Soares Egypto de Brito  12 , Tatiana Nayara Libório-Kimura  13 , Maria Carmen Lopes Ferreira Silva Santos  14 , Diego Ustárroz Cantali  15 , Juliana D 'Agostino Gennari  16 , Karina Gatz Capobianco  17 , Vinicius Tassoni Civile  1 , Ana Carolina Pereira Nunes Pinto  1   18 , Aline Pereira da Rocha  1 , César Ramos Rocha-Filho  1 , Fabiola Reis Oliveira  19 , Valeria Valim  20
Affiliations
Meta-Analysis

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic)

Virginia Fernandes Moça Trevisani et al. Adv Rheumatol. .

Abstract

Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, some systemic manifestations, mainly liver, gastrointestinal, and pancreatic are not routinely evaluated. To address these manifestations, the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology conducted a broad systematic review of the literature on studies investigating prevalence and diagnosis of these symptoms in Sjogren´s patients and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. This is the second part of this guideline, providing 6 recommendations for liver, gastrointestinal, and pancreatic care of SS patients.

Keywords: Clinical guidelines; Gastrointestinal diseases; Sjögren’s syndrome.

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