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. 2022 Aug 29;7(10):2317-2318.
doi: 10.1016/j.ekir.2022.08.020. eCollection 2022 Oct.

Concomitant Anti-GBM Glomerulonephritis and Acute Interstitial Nephritis Following Programmed Death Receptor-1 Blockade With Nivolumab

Takashi Tani  1   2 , Kenta Sugino  1   2 , Kazumasa Hashimoto  1   2 , Akiko Mii  1 , Tetsuya Kashiwagi  1 , Akira Shimizu  3 , Yukinao Sakai  1 , Masato Iwabu  1
Affiliations

Concomitant Anti-GBM Glomerulonephritis and Acute Interstitial Nephritis Following Programmed Death Receptor-1 Blockade With Nivolumab

Takashi Tani et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Kidney biopsy findings reveal necrotizing crescentic glomerulonephritis with linear IgG and C3 distribution along the GBM and TIN with infiltration of inflammatory cells. (a,b) Glomerulus revealed diffuse necrotizing crescentic glomerulonephritis characterized by cellular crescents with GBM ruptures and fibrin deposition (a, Masson stain; b, PAM stain, 400x). (c,d) Immunofluorescence of the glomeruli staining for IgG and C3 reveals linear distribution along the GBM (FITC, 400x). (e, f) TIN with interstitial infiltrating inflammatory cells, mainly eosinophils and mononuclear cells, was noted. (e, Masson stain, 100x; f, HE stain, 400x) (g–j) CD4-positive and CD8-positive lymphocytes (CD8>CD4) were colocalized with CD20-positive B cells and CD68-positive macrophages in the tubule stroma, which indicates that both T cells and B cells played a role. Immunohistochemical staining, 100x. GBM, glomerular basement membrane; HE, hematoxylin and eosin; Masson, Masson’s trichrome; PAM, periodic acid-methenamine-silver; TIN, tubulointerstitial nephritis; Masson, Masson’s trichrome.
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