Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Oct 11;16(10):e01619.
doi: 10.1213/XAA.0000000000001619. eCollection 2022 Oct 1.

Severe Polyethylene Glycol Allergy Considerations for Perioperative Management: A Case Report

Annie Wong-On-Wing  1 , Kenneth Ruth  1   2 , Kelly Hinerth  3 , Alexandra Deng  3 , Maereg Woldekiros  3 , Richard G Ellenbogen  1   4 , C Michael Crowder  1   2   5
Affiliations
Case Reports

Severe Polyethylene Glycol Allergy Considerations for Perioperative Management: A Case Report

Annie Wong-On-Wing et al. A A Pract. .

Abstract

Patients with severe polyethylene glycol (PEG) allergies face broad challenges, especially when presenting to the hospital for surgery, as PEG is used often as an excipient in medications and in medical supplies. Although rare, this allergy is increasingly reported and likely underdiagnosed. We present a patient with known past anaphylactic reaction to PEG and a detailed account of her perioperative course. More broadly, we provide recommendations and resources for the safe management of similar patients with a severe PEG allergy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Cox F, Khalib K, Conlon N. PEG that reaction: a case series of allergy to polyethylene glycol. J Clin Pharmacol. 2021;61:832–835.
    1. Zhou ZH, Stone CA Jr, Jakubovic B, et al. Anti-PEG IgE in anaphylaxis associated with polyethylene glycol. J Allergy Clin Immunol Pract. 2021;9:1731–1733.e3.
    1. Nilsson L, Csuth Á, Storsaeter J, Garvey LH, Jenmalm MC. Vaccine allergy: evidence to consider for COVID-19 vaccines. Curr Opin Allergy Clin Immunol. 2021;21:401–409.
    1. Bruusgaard-Mouritsen MA, Johansen JD, Garvey LH. Clinical manifestations and impact on daily life of allergy to polyethylene glycol (PEG) in ten patients. Clin Exp Allergy. 2021;51:463–470.
    1. Sellaturay P, Nasser S, Ewan P. Polyethylene glycol-induced systemic allergic reactions (anaphylaxis). J Allergy Clin Immunol Pract. 2021;9:670–675.

Publication types