Cold exposure as anti-cancer therapy
- PMID: 36220071
- DOI: 10.1016/j.ccell.2022.09.008
Cold exposure as anti-cancer therapy
Abstract
Seki et al. report in Nature that increasing glucose catabolism in brown adipose tissue by cold exposure lowers blood glucose and insulin tolerance. This systemic effect on body metabolism decreases glucose catabolism in tumors and arrests tumor progression, offering a novel alternative approach for metabolism-based cancer therapy.
Copyright © 2022. Published by Elsevier Inc.
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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Brown-fat-mediated tumour suppression by cold-altered global metabolism.Nature. 2022 Aug;608(7922):421-428. doi: 10.1038/s41586-022-05030-3. Epub 2022 Aug 3. Nature. 2022. PMID: 35922508 Free PMC article.
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