Building a kidney tree: Functional collecting duct from human pluripotent stem cells
- PMID: 36220079
- DOI: 10.1016/j.devcel.2022.09.009
Building a kidney tree: Functional collecting duct from human pluripotent stem cells
Abstract
Human developmental studies and regenerative therapies need in vitro systems that generate cell types recapitulating mature cell physiologies. In a recent issue of Nature Biotechnology, Shi et al. (2022) show how pluripotent stem cells can differentiate into ureteric bud organoids that mature into functional kidney collecting duct cell types.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types.Nat Biotechnol. 2023 Feb;41(2):252-261. doi: 10.1038/s41587-022-01429-5. Epub 2022 Aug 29. Nat Biotechnol. 2023. PMID: 36038632 Free PMC article.
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