Association between olfactory dysfunction and motor subtypes in Parkinson's disease: are non-tremor-dominant subtypes really uncorrelated to olfactory impairment?

Claudia Frau^#¹, Carla Masala^#², Paolo Solla^#^{3

4}, Tommaso Ercoli⁵, Giovanni Defazio⁵

Affiliations

¹ Neurology Unit, Azienza Ospedaliera Universitaria (AOU) Sassari, Viale S. Pietro 10, 07100, Sassari, Italy.
² Department of Biomedical Sciences, University of Cagliari, SP 8 Cittadella Universitaria, 09042, Monserrato, Italy.
³ Neurology Unit, Azienza Ospedaliera Universitaria (AOU) Sassari, Viale S. Pietro 10, 07100, Sassari, Italy. psolla@uniss.it.
⁴ Department of Medicine, Surgery e Pharmacy, University of Sassari, Viale San Pietro 12, 07100, Sassari, Italy. psolla@uniss.it.
⁵ Institute of Neurology, Azienda Ospedaliero Universitaria Di Cagliari, SS 554 km 4.500, 09042, Cagliari, Italy.

^# Contributed equally.

Comment

Claudia Frau et al. Neurol Sci. 2023 Feb.

. 2023 Feb;44(2):729-730.

doi: 10.1007/s10072-022-06445-6. Epub 2022 Oct 11.

Claudia Frau^#¹, Carla Masala^#², Paolo Solla^#^{3

4}, Tommaso Ercoli⁵, Giovanni Defazio⁵

¹ Neurology Unit, Azienza Ospedaliera Universitaria (AOU) Sassari, Viale S. Pietro 10, 07100, Sassari, Italy.
² Department of Biomedical Sciences, University of Cagliari, SP 8 Cittadella Universitaria, 09042, Monserrato, Italy.
³ Neurology Unit, Azienza Ospedaliera Universitaria (AOU) Sassari, Viale S. Pietro 10, 07100, Sassari, Italy. psolla@uniss.it.
⁴ Department of Medicine, Surgery e Pharmacy, University of Sassari, Viale San Pietro 12, 07100, Sassari, Italy. psolla@uniss.it.
⁵ Institute of Neurology, Azienda Ospedaliero Universitaria Di Cagliari, SS 554 km 4.500, 09042, Cagliari, Italy.

^# Contributed equally.

No abstract available

Comment on

Olfactory dysfunction is associated with motor function only in tremor-dominant Parkinson's disease.
Nabizadeh F, Pirahesh K, Khalili E. Nabizadeh F, et al. Neurol Sci. 2022 Jul;43(7):4193-4201. doi: 10.1007/s10072-022-05952-w. Epub 2022 Feb 15. Neurol Sci. 2022. PMID: 35166976
Olfactory dysfunction and striatal dopamine transporter binding in motor subtypes of Parkinson's disease.
Nabizadeh F, Sodeifian F, Pirahesh K. Nabizadeh F, et al. Neurol Sci. 2022 Aug;43(8):4745-4752. doi: 10.1007/s10072-022-06110-y. Epub 2022 May 4. Neurol Sci. 2022. PMID: 35508569

1. Nabizadeh F, Pirahesh K, Khalili E (2022) Olfactory dysfunction is associated with motor function only in tremor-dominant Parkinson’s disease. Neurol Sci 43(7):4193–4201 - DOI
1. Nabizadeh F, Sodeifian F, Pirahesh K (2022) Olfactory dysfunction and striatal dopamine transporter binding in motor subtypes of Parkinson’s disease. Neurol Sci 43(8):4745–4752 - DOI
1. Solla P, Masala C, Ercoli T, Orofino G, Loy F, Pinna I, Fadda L, Defazio G (2022) Olfactory impairment in Parkinson’s disease patients with tremor dominant subtype compared to those with akinetic rigid dominant subtype: A Pilot Study. Brain Sci 31;12(2):196
1. Doty RL, Shaman P, Kimmelman CP, Dann MS (1984) University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 94:176–178 - DOI
1. Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3000 subjects. Eur Arch Oto- Rhino-Laryngol 264(3):237–243 - DOI