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Review
. 2023 Mar 1;30(2):86-94.
doi: 10.1097/PAP.0000000000000376. Epub 2022 Oct 12.

DEK::AFF2 Fusion Carcinomas of Head and Neck

Komkrit Ruangritchankul  1 , Ann Sandison  2
Affiliations
Review

DEK::AFF2 Fusion Carcinomas of Head and Neck

Komkrit Ruangritchankul et al. Adv Anat Pathol. .

Abstract

A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkeratinizing squamous cell carcinoma. The tumors occurred at multiple sites in the head and neck including in the sinonasal tract, middle ear, and temporal bone. This tumor behaves aggressively involving adjacent vital structures, frequently recurs, and is inclined to develop lymph node and distant metastasis. This review aims to summarize the demographic, clinical, pathologic, immunophenotypic features, and pattern of molecular alterations as well as to discuss the differential diagnosis of DEK::AFF2 fusion carcinoma.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

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MeSH terms