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Practice Guideline
. 2022 Dec;69(12):e30001.
doi: 10.1002/pbc.30001. Epub 2022 Oct 11.

Prevention of acute and delayed chemotherapy-induced nausea and vomiting in pediatric cancer patients: A clinical practice guideline

Priya Patel  1   2 , Paula D Robinson  1 , Marie Cohen  3 , Katie Devine  4 , Paul Gibson  1   5 , Mark T Holdsworth  6 , Eloise Neumann  7 , Andrea Orsey  8   9 , Robert Phillips  10 , Daniela Spinelli  3 , Jennifer Thackray  11 , Marianne van de Wetering  12 , Deborah Woods  13 , Sandra Cabral  1 , Lillian Sung  14   15 , L Lee Dupuis  2   15   16
Affiliations
Practice Guideline

Prevention of acute and delayed chemotherapy-induced nausea and vomiting in pediatric cancer patients: A clinical practice guideline

Priya Patel et al. Pediatr Blood Cancer. 2022 Dec.

Abstract

This clinical practice guideline provides recommendations for preventing acute and delayed phase chemotherapy-induced nausea and vomiting (CINV) in pediatric patients. The recommendations are based on two systematic reviews of randomized controlled trials evaluating interventions to prevent (1) acute phase CINV and (2) delayed phase CINV. Recommendations for acute phase and delayed phase CINV prophylaxis are made for patients receiving chemotherapy of varying emetogenicity, as well as for patients not able to receive dexamethasone or a neurokinin-1 receptor antagonist. Evidence gaps, including antiemetic safety and optimal dosing, were identified.

Keywords: chemotherapy-induced nausea and vomiting; guideline; pediatric oncology; supportive care.

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References

REFERENCES

    1. Sommariva S, Pongiglione B, Tarricone R. Impact of chemotherapy-induced nausea and vomiting on health-related quality of life and resource utilization: A systematic review. Crit Rev Oncol Hematol 2016:99:13-36.
    1. Peoples AR, Roscoe JA, Block RC, et al. Nausea and disturbed sleep as predictors of cancer-related fatigue in breast cancer patients: a multicenter NCORP study. Support Care Cancer 2017:25(4):1271-1278.
    1. Neymark N, Crott R. Impact of emesis on clinical and economic outcomes of cancer therapy with highly emetogenic chemotherapy regimens: a retrospective analysis of three clinical trials. Support Care Cancer 2005:13(10):812-818.
    1. Schwartzberg LS, Navari RM, Ruddy KJ, et al. Work loss and activity impairment due to duration of nausea and vomiting in patients with breast cancer receiving CINV prophylaxis. Journal of Clinical Oncology 2020:38(15_suppl):e24133-e24133.
    1. Flank J, Sparavalo J, Vol H, et al. The burden of chemotherapy-induced nausea and vomiting in children receiving hematopoietic stem cell transplantation conditioning: a prospective study. Bone Marrow Transplant 2017:52(9):1294-1299.

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