Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May;75(5):427-439.
doi: 10.1002/iub.2681. Epub 2022 Oct 27.

Mechanisms of epigenetic regulation of transcription by lncRNAs in plants

Benjamin J M Tremblay  1 , Julia I Qüesta  1
Affiliations
Free article
Review

Mechanisms of epigenetic regulation of transcription by lncRNAs in plants

Benjamin J M Tremblay et al. IUBMB Life. 2023 May.
Free article

Abstract

Long noncoding RNAs (lncRNAs) are an ubiquitous feature of eukaryotic genomes and in recent decades have been shown to be highly abundant and varied. Many prominent examples have been described as having essential roles in regulating the expression of genes in different developmental and environmental contexts. As a result, much work has been done on elucidating the mechanisms by which they modulate the expression of protein coding genes. In this review, we focus on those which have been characterized in plants. We specifically examine common epigenetic mechanisms that regulate gene expression at the level of transcription. In this regard, we focus on the lncRNAs in plants that have primarily been associated with controlling the chromatin environment of genes at the level of modifications, RNA POLYMERASE II (RNAPII) processivity and efficiency of transcription, and mediating the formation of transcriptionally activating and repressive chromatin loops. We discuss open questions in plant lncRNA epigenetic regulation and opportunities for future study of functionally significant lncRNAs with yet-unknown epigenetic mechanisms.

Keywords: Chromatin; RNA polymerase; epigenetics; gene regulation; lncRNAs; plants.

PubMed Disclaimer

References

REFERENCES

    1. Anderson DM, Anderson KM, Chang C-L, et al. A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. Cell. 2015;160:595-606. https://doi.org/10.1016/j.cell.2015.01.009.
    1. Bardou F, Merchan F, Ariel F, Crespi M. Dual RNAs in plants. Biochimie. 2011;93:1950-1954. https://doi.org/10.1016/j.biochi.2011.07.028.
    1. Huang J-Z, Chen M, Chen D, et al. A peptide encoded by a putative lncRNA HOXB-AS3 suppresses colon cancer growth. Mol Cell. 2017;68:171-184.e6. https://doi.org/10.1016/j.molcel.2017.09.015.
    1. Hubé F, Velasco G, Rollin J, Furling D, Francastel C. Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation. Nucleic Acids Res. 2010;39:513-525. https://doi.org/10.1093/nar/gkq833.
    1. Verheggen K, Volders P-J, Mestdagh P, Menschaert G, Van Damme P, et al. Noncoding after all: Biases in proteomics data do not explain observed absence of lncRNA translation products. J Proteome Res. 2017;16:2508-2515. https://doi.org/10.1021/acs.jproteome.7b00085.

Publication types

LinkOut - more resources