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The expectations for the clinical application of stem cell therapy for diabetic microvascular complications are increasing, as stem cell transplantation improves histopathological abnormalities mainly through angiogenesis/protection, nerve elongation/protection, and anti-inflammatory effects.
Omi M, Hata M, Nakamura N, et al. Transplantation of dental pulp stem cells improves long‐term diabetic polyneuropathy together with improvement of nerve morphometrical evaluation. Stem Cell Res Ther 2017; 8: 279.
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Omi M, Hata M, Nakamura N, et al. Transplantation of dental pulp stem cells suppressed inflammation in sciatic nerves by promoting macrophage polarization towards anti‐inflammation phenotypes and ameliorated diabetic polyneuropathy. J Diabetes Investig 2016; 7: 485–496.
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Xiang E, Han B, Zhang Q, et al. Human umbilical cord‐derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Res Ther 2020; 11: 1–14.
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Zhang W, Wang Y, Kong J, et al. Therapeutic efficacy of neural stem cells originating from umbilical cord‐derived mesenchymal stem cells in diabetic retinopathy. Sci Rep 2017; 7: 1–8.
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Takemura S, Shimizu T, Oka M, et al. Transplantation of adipose‐derived mesenchymal stem cell sheets directly into the kidney suppresses the progression of renal injury in a diabetic nephropathy rat model. J Diabetes Investig 2020; 11: 545–553.
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