Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Feb;37(2):e127-e129.
doi: 10.1111/jdv.18653. Epub 2022 Oct 31.

A case of Anti-MDA5-Positive dermatomyositis after inactivated COVID-19 vaccine

Lili Yang  1   2 , Tinglu Ye  1 , Huanyu Liu  3 , Cong Huang  1 , Weiwei Tian  1 , Yueming Cai  4
Affiliations
Case Reports

A case of Anti-MDA5-Positive dermatomyositis after inactivated COVID-19 vaccine

Lili Yang et al. J Eur Acad Dermatol Venereol. 2023 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The first author is the wife of the patient, the other authors have no potential conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Dermatological rash in the patient. Erythematous rash appeared on the fingers (a), arrows point to the desquamate red patchy rash on the index finger, elbow (b), and back (c) of the patient, necrosis in the fingertips (arrow in d), swelling appeared on the hands (circled in the e), the fingerprint was not available due to swelling, while vasculitis formed on the fingertips (arrows) of the patient. Gottron's papulars on both hands of the patient. Papulars appeared on the knuckles and palmar joints (arrow in f) and vascular damage on the nailfold (arrow in g).
FIGURE 2
FIGURE 2
Skin biopsy on the back and high‐resolution computed tomography imaging of the chest. Arrowheads marked vacuolar interface (a), lymphocytes and erythrocytes infiltration in the superficial perivascular (c). Increased amounts of mucin and lymphocytes in the dermis (d). Magnification: (a) 400×; (b) 10×; (c) 400×; (d) 10×. Scattered patchy, flocculent ground glass density shadow on both lungs (arrow in e), nodules (arrow in f).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Cho K, Park S, Kim EY, Koyanagi A, Jacob L, Yon DK, et al. Immunogenicity of COVID‐19 vaccines in patients with diverse health conditions: a comprehensive systematic review. J Med Virol. 2022;94(9):4144–55. - PMC - PubMed
    1. Wu M, Karim M, Ashinoff R. COVID‐19 vaccine‐associated dermatomyositis. JAAD Case Rep. 2022;23:58–60. - PMC - PubMed
    1. Gonzalez D, Gupta L, Murthy V, Gonzalez EB, Williamson KA, Makol A, et al. Anti‐MDA5 dermatomyositis after COVID‐19 vaccination: a case‐based review. Rheumatol Int. 2022;42(9):1629–41. - PMC - PubMed
    1. Carrasco L, Arthur A, Gaitan RJ, Case C. A rapidly progressive and rare illness: autoantibodies against melanoma diferentiation‐associated protein 5 (anti‐MDA5): amyopathic dermatomyositis with progressive interstitial lung disease that developed after covid‐19 vaccine. Chest J. 2021;160(4):A680–1.
    1. Lundberg IE, Tjarnlund A, Bottai M, Werth VP, Pilkington C, de Visser M, et al. 2017 European league against rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis. 2017;76(12):1955–64. - PMC - PubMed

MeSH terms