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. 2022 Nov 3;387(18):1716-1718.
doi: 10.1056/NEJMc2211055. Epub 2022 Oct 12.

Immune Imprinting and Protection against Repeat Reinfection with SARS-CoV-2

Hiam Chemaitelly  1 , Houssein H Ayoub  2 , Patrick Tang  3 , Mohammad R Hasan  3 , Peter Coyle  4 , Hadi M Yassine  2 , Hebah A Al-Khatib  2 , Maria K Smatti  2 , Zaina Al-Kanaani  4 , Einas Al-Kuwari  4 , Andrew Jeremijenko  4 , Anvar H Kaleeckal  4 , Ali N Latif  4 , Riyazuddin M Shaik  4 , Hanan F Abdul-Rahim  2 , Gheyath K Nasrallah  2 , Mohamed G Al-Kuwari  5 , Adeel A Butt  4 , Hamad E Al-Romaihi  6 , Mohamed H Al-Thani  6 , Abdullatif Al-Khal  4 , Roberto Bertollini  6 , Laith J Abu-Raddad  7
Affiliations

Immune Imprinting and Protection against Repeat Reinfection with SARS-CoV-2

Hiam Chemaitelly et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Incidence of SARS-CoV-2 Reinfection in the Double-Primed and Omicron-Primed Cohorts.
The double-primed cohort included persons with a documented reinfection with B.1.1.529 (omicron) subvariant BA.1 or BA.2 after a primary infection with pre-omicron severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the omicron-primed cohort included persons with a documented primary infection with an omicron BA.1 or BA.2 subvariant. The inset in Panel A shows the same data on an expanded y axis. The main analysis included the full matched cohorts; in an additional analysis (Panel B), the double-primed cohort included only persons whose primary infection had been with the original virus or the B.1.1.7 (alpha) variant. Hazard ratios were adjusted for the factors used for matching. This study was conducted in Qatar between December 19, 2021, and August 15, 2022. Follow-up started 90 days after documentation of reinfection. The median duration of follow-up was 125 days (interquartile range, 114 to 132) in each cohort.
See this image and copyright information in PMC

References

    1. Reynolds CJ, Pade C, Gibbons JM, et al. Immune boosting by B.1.1.529 (omicron) depends on previous SARS-CoV-2 exposure. Science 2022;377(6603):eabq1841-eabq1841. - PMC - PubMed
    1. Chemaitelly H, Ayoub HH, Coyle P, et al. Protection of omicron sub-lineage infection against reinfection with another omicron sub-lineage. Nat Commun 2022;13:4675-4675. - PMC - PubMed
    1. Altarawneh HN, Chemaitelly H, Ayoub HH, et al. Effects of previous infection and vaccination on symptomatic omicron infections. N Engl J Med 2022;387:21-34. - PMC - PubMed
    1. Altarawneh HN, Chemaitelly H, Ayoub HH, et al. Protective effect of previous SARS-CoV-2 infection against omicron BA.4 and BA.5 subvariants. N Engl J Med. DOI: 10.1056/NEJMc2209306. - DOI - PMC - PubMed

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