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. 2023 Jun;35(6):818-823.
doi: 10.1080/09540121.2022.2132371. Epub 2022 Oct 12.

Pregnancy and birth outcomes among young women living with perinatally acquired HIV in Thailand and Vietnam

Pagakrong Lumbiganon  1 , Azar Kariminia  2 , Suvaporn Anugulruengkitt  3   4 , Pradthana Ounchanum  5 , Sukanda Denjanta  5 , Thanyawee Puthanakit  3   4 , Pope Kosalaraksa  1 , Tavitiya Sudjaritruk  6   7 , Chanidapa Detsakunathiwatchara  8 , Viet Chau Do  9 , An Thien Vu  9 , Lam Van Nguyen  10 , Giang Thi Thanh Thuy  10 , Tulathip Suwanlerk  11 , Annette H Sohn  11 , IeDEA Asia-Pacific
Affiliations

Pregnancy and birth outcomes among young women living with perinatally acquired HIV in Thailand and Vietnam

Pagakrong Lumbiganon et al. AIDS Care. 2023 Jun.

Abstract

We conducted a retrospective cohort study of pregnancy and infant outcomes in 670 adolescents and young adult women with perinatally acquired HIV (AYAPHIV), aged 15-24 years, in Thailand and Vietnam. Between January 2013 and December 2018, there were 52 pregnancies, for an incidence of 2.49 (95% CI 1.90-3.27) per 100 person-years. The median age at pregnancy was 17.7 years (IQR 16.8-18.9). Pregnant AYAPHIV had been on cART for a lifetime median of 9.8 years (IQR 7.3-12.4). At the time of conception, the median CD4 was 521 cells/mm3 (IQR 213-760), and 76% had HIV RNA ≤400 copies/ml. Of the 51 pregnancies with available outcomes, 90% resulted in live singleton births at a median gestational age of 38 weeks (IQR 37-39); 77% of mothers (n = 27/35) had HIV RNA ≤400 copies/ml at delivery. Among infants with available data, 50% (n = 21/42) were male and 29% (n = 12/42) were reported to be low birthweight (<2,500gm); none (n = 0/41) were breastfed. One infant was diagnosed with HIV. Our findings emphasize that efforts to strengthen reproductive health education, including contraception, pregnancy-related psychosocial support services, and prevention of vertical HIV transmission interventions, in our region are needed for adolescents with perinatally acquired HIV as they transition to young adults.

Keywords: HIV; birth outcomes; perinatal; pregnancy; women; youth.

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Figures

Figure 1.
Figure 1.
Participant flow diagram for inclusion in the analysis (N=670)
See this image and copyright information in PMC

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