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Comment
. 2022 Oct 11;55(10):1761-1763.
doi: 10.1016/j.immuni.2022.09.011.

Cytokines drive prostate cancer lineage plasticity

Jie Li  1 , Brian Ruffell  2
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Comment

Cytokines drive prostate cancer lineage plasticity

Jie Li et al. Immunity. .
Free article

Abstract

Lineage plasticity is a critical mechanism of therapeutic resistance in cancer. In a recent issue of Science, Chan and colleagues demonstrate that early lineage plasticity in prostate cancer is driven by JAK-STAT inflammatory cytokine signaling.

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Conflict of interest statement

Declaration of interests B.R. has a courtesy faculty appointment at the University of South Florida.

Comment on

  • Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling.
    Chan JM, Zaidi S, Love JR, Zhao JL, Setty M, Wadosky KM, Gopalan A, Choo ZN, Persad S, Choi J, LaClair J, Lawrence KE, Chaudhary O, Xu T, Masilionis I, Linkov I, Wang S, Lee C, Barlas A, Morris MJ, Mazutis L, Chaligne R, Chen Y, Goodrich DW, Karthaus WR, Pe'er D, Sawyers CL. Chan JM, et al. Science. 2022 Sep 9;377(6611):1180-1191. doi: 10.1126/science.abn0478. Epub 2022 Aug 18. Science. 2022. PMID: 35981096 Free PMC article.

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