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Comment
. 2022 Oct 12;7(1):363.
doi: 10.1038/s41392-022-01214-5.

Segregating memories: targeting microenvironment of neuronal ensembles

Ying Liu #  1 , Miao Xu #  1 , Wei-Guang Li  2
Affiliations
Comment

Segregating memories: targeting microenvironment of neuronal ensembles

Ying Liu et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
CCR5 regulates the overlap of neuronal ensembles for different memories, thereby altering the temporal window for memory linking. a Distinct neuronal ensembles are responsible for memories in different contexts. The red- and green-colored neurons represent neuronal ensembles for memories of context A and context B, respectively. b A modified contextual fear conditioning as the behavioral paradigm to assess memory linking. Mice were placed in context A, followed by a changeable temporal window (5-h as a typical temporal window) before being placed in context B. Two days later, the mice received footshocks in context B. The presence of a significant fear response in context A indicates effective memory linking. c The activity and expression levels of CCR5 determine the temporal window for memory linking. While young adult mice with a 5-h temporal window between exposure to contexts A and B showed effective memory linking, mice with the same temporal window but with ectopic activation of CCR5 in the hippocampal CA1 region or injected with CCL5 protein showed insignificant memory linking. Likewise, young adult mice with a longer temporal window (up to 2 days) showed insignificant memory linking. Middle-aged mice displayed higher CCR5 expression in the hippocampal CA1 region and failed to show memory linking in the 5-h group, which was reversed following administration of the FDA-approved CCR5 antagonist maraviroc. The orange-colored neurons represent the overlapped neuronal ensembles that link memories of context A and context B
See this image and copyright information in PMC

Comment on

  • CCR5 closes the temporal window for memory linking.
    Shen Y, Zhou M, Cai D, Filho DA, Fernandes G, Cai Y, de Sousa AF, Tian M, Kim N, Lee J, Necula D, Zhou C, Li S, Salinas S, Liu A, Kang X, Kamata M, Lavi A, Huang S, Silva T, Heo WD, Silva AJ. Shen Y, et al. Nature. 2022 Jun;606(7912):146-152. doi: 10.1038/s41586-022-04783-1. Epub 2022 May 25. Nature. 2022. PMID: 35614219 Free PMC article.

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