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. 2023 Jan;58(1):288-296.
doi: 10.1002/ppul.26199. Epub 2022 Oct 20.

Cardiac function in bronchiolitis: Not only a right ventricle matter

Maria L Rossi  1   2 , Stephanie M Hadley  3 , Paula C Randanne  1 , Maria C Escobar-Diaz  1   2 , Marta C Camprubi  2   4 , Iolanda Jordan  5   6   7 , Joan Sanchez-de-Toledo  1   2   8
Affiliations

Cardiac function in bronchiolitis: Not only a right ventricle matter

Maria L Rossi et al. Pediatr Pulmonol. 2023 Jan.

Abstract

Objectives: Extrapulmonary manifestations of bronchiolitis have been previously studied, with some identifying right ventricle (RV) diastolic/systolic dysfunction. We hypothesized that severe cases of bronchiolitis would have cardiac dysfunction resulting an increase in N-terminal pro-hormone B-type natriuretic peptide (NT-proBNP) values and worse outcomes. Therefore, the objective was to evaluate the existence of cardiac dysfunction and to determine its association with severe bronchiolitis.

Methods: This prospective cohort study included children hospitalized for bronchiolitis under 1-year old between January 2019 and March 2020. At admission, an echocardiography was performed and plasma levels of NT-proBNP were measured. To analyze outcomes, the cohort was divided into two groups based on the need for positive pressure respiratory support (PPRS), and both were compared to healthy infants.

Statistics: bivariant analysis, significant differences p < 0.05.

Results: One hundred eighty-one patients were included; median age was 2 months. Seventy-three patients required PPRS. Compared to controls, patients requiring PPRS showed worse RV systolic function, with lower tricuspid annular-plane systolic excursion (p = 0.002) and parameters of worse right and left diastolic function (trans-tricuspid E and A wave [p = 0.004 and p = 0.04, respectively] and tricuspid tissue doppler imaging [TDI] e' [p = 0.003], trans-mitral E and mitral TDI a' [p = 0.02 and p = 0.005, respectively]). An NT-ProBNP greater than 3582 pg/dl predicts the need for longer necessity of PPRS in patients younger than 2 months.

Conclusions: In addition to the expected RV systolic dysfunction, patients with severe bronchiolitis have parameters of global diastolic worse function possibly secondary to intrinsic myocardial involvement. NT-ProBNP values at admission had strong discriminatory power to predict worse outcomes.

Keywords: NT-proBNP; diastolic cardiac dysfunction; systolic cardiac dysfunction.

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References

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