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Review
. 2022 Nov 1;30(6):490-500.
doi: 10.4062/biomolther.2022.114. Epub 2022 Oct 13.

Senotherapeutics and Their Molecular Mechanism for Improving Aging

Jooho Park  1 , Dong Wook Shin  2
Affiliations
Review

Senotherapeutics and Their Molecular Mechanism for Improving Aging

Jooho Park et al. Biomol Ther (Seoul). .

Abstract

Aging is defined as physiological dysfunction of the body and a key risk factor for human diseases. During the aging process, cellular senescence occurs in response to various extrinsic and intrinsic factors such as radiation-induced DNA damage, the activation of oncogenes, and oxidative stress. These senescent cells accumulate in many tissues and exhibit diverse phenotypes, such as resistance to apoptosis, production of senescence-associated secretory phenotype, cellular flattening, and cellular hypertrophy. They also induce abnormal dysfunction of the microenvironment and damage neighboring cells, eventually causing harmful effects in the development of various chronic diseases such as diabetes, cancer, and neurodegenerative diseases. Thus, pharmacological interventions targeting senescent cells, called senotherapeutics, have been extensively studied. These senotherapeutics provide a novel strategy for extending the health span and improving age-related diseases. In this review, we discuss the current progress in understanding the molecular mechanisms of senotherapeutics and provide insights for developing senotherapeutics.

Keywords: Aging; Molecular mechanism; Senescence; Senotherapeutics.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors have no conflicting interests.

Figures

Fig. 1
Fig. 1
Molecular targets of senolytics and senomorphics. Each senotherapeutic and its target are shown at the cellular level.
See this image and copyright information in PMC

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