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. 1987 Aug 15;43(8):892-4.
doi: 10.1007/BF01951654.

The synthesis of stereoselectively labelled porphobilinogen and its incorporation into protoporphyrin-IX

A H Jackson, W Lertwanawatana, G Procter, S G Smith

The synthesis of stereoselectively labelled porphobilinogen and its incorporation into protoporphyrin-IX

A H Jackson et al. Experientia. .

Abstract

11-(R)-2H porphobilinogen, stereospecifically labelled with deuterium in the aminomethylene group has been incorporated into protoporphyrin-IX by haemolysates of chicken erythrocytes. High field NMR spectroscopy confirms that the overall biochemical process is stereospecific, deuterium being retained at the alpha-, gamma- and delta-meso positions and lost from the beta-meso position.

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References

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