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. 2023:2553:79-94.
doi: 10.1007/978-1-0716-2617-7_5.

From Genome Mining to Protein Engineering: A Structural Bioinformatics Route

Derek J Smith  1
Affiliations

From Genome Mining to Protein Engineering: A Structural Bioinformatics Route

Derek J Smith. Methods Mol Biol. 2023.

Abstract

This chapter outlines applications in genome mining, along with computational methods to predict protein structure and protein-ligand docking. It offers a simple computational route to rapidly identify proteins of interest from genomic and proteomic data, to accurately predict their three-dimensional structures, and to dock small molecules to their binding pockets and strategies to improve their biophysical properties depending on the needs of the experimental researcher.

Keywords: Directed evolution; Genome mining; Protein engineering; Protein structure prediction; Small molecule docking; Structural bioinformatics.

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