A novel and highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia

Affiliations

¹ WHO Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
² WHO Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; Sydney Institute for Infectious Diseases, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia; Department of Microbiology and Immunology, at The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address: michelle.wille@sydney.edu.au.
³ CSIRO, Australian Centre for Disease Preparedness, Geelong, Victoria, Australia.
⁴ The Office of Research Ethics and Integrity, The University of Melbourne, Melbourne, Victoria, Australia.
⁵ WHO Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; Department of Microbiology and Immunology, at The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
⁶ WHO Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; Department of Microbiology and Immunology, at The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address: ian.barr@influenzacentre.org.

PMID: 36228351
DOI: 10.1016/j.virol.2022.09.001

A novel and highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia

Ankita M George et al. Virology. 2022 Nov.

. 2022 Nov:576:117-126.

doi: 10.1016/j.virol.2022.09.001. Epub 2022 Sep 21.

Authors

Affiliations

¹ WHO Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
² WHO Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; Sydney Institute for Infectious Diseases, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia; Department of Microbiology and Immunology, at The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address: michelle.wille@sydney.edu.au.
³ CSIRO, Australian Centre for Disease Preparedness, Geelong, Victoria, Australia.
⁴ The Office of Research Ethics and Integrity, The University of Melbourne, Melbourne, Victoria, Australia.
⁵ WHO Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; Department of Microbiology and Immunology, at The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
⁶ WHO Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; Department of Microbiology and Immunology, at The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address: ian.barr@influenzacentre.org.

PMID: 36228351
DOI: 10.1016/j.virol.2022.09.001

Abstract

Canine distemper virus (CDV) causes a highly contagious systemic infection in an array of animal species. In this study we report an outbreak of distemper in ferrets in two research facilities in Australia, caused by a novel lineage of CDV. While the CDV strain caused mainly mild symptoms in ferrets, histopathology results presented a typical profile of distemper pathology, with multi-system virus replication. Through the development of a discriminatory PCR, paired with full genome sequencing, we revealed that the outbreak was caused by a novel lineage of CDV. The novel CDV lineage was highly divergent, with less than 93% similarity across the H gene to other described lineages, including the vaccine strain, and diverged approximately 140-400 years ago. Enhanced surveillance to determine the prevalence of CDV in ferrets, dogs and other at-risk species is critical to better understand the presence and diversity of CDV in Australia currently.

Keywords: Australia; CDV; Canine distemper virus; Canine morbillivirus; Ferrets; Paramyxoviridae.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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A novel and highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia

Affiliations

A novel and highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources