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. 2022 Nov 1;68(11):e173-e178.
doi: 10.1097/MAT.0000000000001820. Epub 2022 Oct 12.

Bioprosthetic Total Artificial Heart Implantation Does Not Induce Chronic Inflammation

Christophe Peronino  1   2   3 , Coralie L Guerin  4   5 , Peter Ivak  6 , Léa Guyonnet  4 , Richard Chocron  7 , Grégoire Detriché  1   2 , Christian Latremouille  3 , Maxime Gruest  1   2 , Aurélien Philippe  1   2 , Antoine Capel  6 , Yuri Pya  8 , Anne-Céline Martin  5   9 , Piet Jansen  3 , Nicolas Gendron  1   2 , Ivan Netuka  6 , David M Smadja  1   2
Affiliations

Bioprosthetic Total Artificial Heart Implantation Does Not Induce Chronic Inflammation

Christophe Peronino et al. ASAIO J. .

Abstract

The Aeson total artificial heart (A-TAH) has been developed for patients at risk of death from biventricular failure. We aimed to assess the inflammatory status in nine subjects implanted with the A-TAH in kinetics over one year. Laboratory assessment of leukocyte counts, inflammatory cytokines assay, and peripheral blood mononuclear cell collection before and after A-TAH implantation. Leukocyte counts were not significantly modulated according to time after A-TAH implantation (coefficient of the linear mixed effect model with 95% CI, -0.05 (-0.71 to -0.61); p = 0.44). We explored inflammatory cytokine after A-TAH and did not observe, at any time, a modified profile compared to pre-implantation values (all p -values > 0.05). Finally, we compared the distribution of circulating immune cell subpopulations identified based on sequential expression patterns for multiple clusters of differentiation. None of the population explored had significant modulation during the 12-month follow-up (all p -values > 0.05). In conclusion, using a cytokine multiplex assay combined with a flow cytometry approach, we demonstrated the absence of inflammatory signals in peripheral blood over a period of 12 months following A-TAH implantation.

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Conflict of interest statement

D.M.S., P.I., Y.P. and I.N. received consulting fees from CARMAT. C.P., C.L., A.C. and P.J. are employed by CARMAT-SAS. Other authors have no conflicts of interest to report.

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