Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb;128(3):402-403.
doi: 10.1038/s41416-022-01996-z. Epub 2022 Oct 13.

Koller and the dawn of cancer cytogenetics

Chris J Norbury  1
Affiliations

Koller and the dawn of cancer cytogenetics

Chris J Norbury. Br J Cancer. 2023 Feb.

Abstract

Shortly before the DNA era began, PC Koller described lagging chromosomes and chromosome numerical abnormalities in human carcinomas. While present-day cancer geneticists would question some of Koller's conclusions, this study ultimately contributed to the realisation that chromosomal instability is a widespread feature of solid tumours.

PubMed Disclaimer

Conflict of interest statement

The author declares no competing interests.

Similar articles

See all similar articles

References

    1. Tjio JH, Levan A. The chromosome number of man. Hereditas. 1956;42:1–6. doi: 10.1111/j.1601-5223.1956.tb03010.x. - DOI
    1. Koller PC. Abnormal mitosis in tumours. Br J Cancer. 1947;1:38–47. doi: 10.1038/bjc.1947.5. - DOI - PMC - PubMed
    1. Koller PC. A new technique for mitosis in tumours. Nature. 1942;149:193. doi: 10.1038/149193a0. - DOI
    1. Thompson SL, Bakhoum SF, Compton DA. Mechanisms of chromosomal instability. Curr Biol. 2010;20:R285–95. doi: 10.1016/j.cub.2010.01.034. - DOI - PMC - PubMed
    1. Boveri T. Zur Frage der Entstehung maligner Tumoren. Jena: Gustav Fischer;1914.