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. 2022 Sep 26;19(19):12155.
doi: 10.3390/ijerph191912155.

Systematic Review of Survival Analysis in Leprosy Studies-Including the Following Outcomes: Relapse, Impairment of Nerve Function, Reactions and Physical Disability

Celivane Cavalcanti Barbosa  1 , Gilberto Silva Nunes Bezerra  2 , Amanda Tavares Xavier  3   4 , Maria de Fátima Pessoa Militão de Albuquerque  1 , Cristine Vieira do Bonfim  5   6 , Zulma Maria de Medeiros  3   4 , Wayner Vieira de Souza  1
Affiliations

Systematic Review of Survival Analysis in Leprosy Studies-Including the Following Outcomes: Relapse, Impairment of Nerve Function, Reactions and Physical Disability

Celivane Cavalcanti Barbosa et al. Int J Environ Res Public Health. .

Abstract

Leprosy is a public health problem in South American, African and Oceanian countries. National programs need to be evaluated, and the survival analysis model can aid in the construction of new indicators. The aim of this study was to assess the period of time until the outcomes of interest for patients with or exposed to leprosy by means of survival analysis surveys. This review researched articles using the databases of PubMed, Science Direct, Scopus, Scielo and BVS published in English and Portuguese. Twenty-eight articles from Brazil, India, Bangladesh, the Philippines and Indonesia were included. The Kaplan-Meier method, which derives the log-rank test, and Cox's proportional hazards regression, which obtains the hazard ratio, were applied. The mean follow-up until the following outcomes were: (I) leprosy (2.3 years) in the population who were exposed to it, (II) relapse (5.9 years), (III) clinical manifestations before, during and after treatment-nerve function impairment (5.2 years), leprosy reactions (4.9 years) and physical disability (8.3 years) in the population of patients with leprosy. Therefore, the use of survival analysis will enable the evaluation of national leprosy programs and assist in the decision-making process to face public health problems.

Keywords: epidemiology; leprosy; statistical analysis; survival analysis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram systematic search and review process. * Reporting the number of records identified from each database.
See this image and copyright information in PMC

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