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. 2022 Sep 23;11(19):5599.
doi: 10.3390/jcm11195599.

Association between CHADS2, CHA2DS2-VASc, ATRIA, and Essen Stroke Risk Scores and Functional Outcomes in Acute Ischemic Stroke Patients Who Received Endovascular Thrombectomy

Hyung Jun Kim  1 , Moo-Seok Park  1 , Joonsang Yoo  2 , Young Dae Kim  3 , Hyungjong Park  4 , Byung Moon Kim  5 , Oh Young Bang  6 , Hyeon Chang Kim  7 , Euna Han  8 , Dong Joon Kim  5 , JoonNyung Heo  3 , Jin Kyo Choi  9 , Kyung-Yul Lee  10 , Hye Sun Lee  11 , Dong Hoon Shin  12 , Hye-Yeon Choi  13 , Sung-Il Sohn  4 , Jeong-Ho Hong  4 , Jong Yun Lee  14 , Jang-Hyun Baek  15 , Gyu Sik Kim  16 , Woo-Keun Seo  6 , Jong-Won Chung  6 , Seo Hyun Kim  17 , Sang Won Han  18 , Joong Hyun Park  18 , Jinkwon Kim  2 , Yo Han Jung  10 , Han-Jin Cho  19 , Seong Hwan Ahn  20 , Sung Ik Lee  21 , Kwon-Duk Seo  16 , Yoonkyung Chang  22 , Hyo Suk Nam  3 , Tae-Jin Song  1 ; SECRET Study Investigators
Affiliations

Association between CHADS2, CHA2DS2-VASc, ATRIA, and Essen Stroke Risk Scores and Functional Outcomes in Acute Ischemic Stroke Patients Who Received Endovascular Thrombectomy

Hyung Jun Kim et al. J Clin Med. .

Abstract

Background: CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke risk scores are used to estimate thromboembolism risk. We aimed to investigate the association between unfavorable outcomes and stroke risk scores in patients who received endovascular thrombectomy (EVT). Methods: This study was performed using data from a nationwide, multicenter registry to explore the selection criteria for patients who would benefit from reperfusion therapies. We calculated pre-admission CHADS2, CHA2DS2-VASc, ATRIA, and Essen scores for each patient who received EVT and compared the relationship between these scores and 3-month modified Rankin Scale (mRS) records. Results: Among the 404 patients who received EVT, 213 (52.7%) patients had unfavorable outcomes (mRS 3−6). All scores were significantly higher in patients with unfavorable outcomes than in those with favorable outcomes. Multivariable logistic regression analysis indicated that CHADS2 and the ATRIA score were positively correlated with unfavorable outcomes after adjusting for body mass index and variables with p < 0.1 in the univariable analysis (CHADS2 score: odds ratio [OR], 1.484; 95% confidence interval [CI], 1.290−1.950; p = 0.005, ATRIA score, OR, 1.128; 95% CI, 1.041−1.223; p = 0.004). Conclusions: The CHADS2 and ATRIA scores were positively correlated with unfavorable outcomes and could be used to predict unfavorable outcomes in patients who receive EVT.

Keywords: endovascular thrombectomy; functional outcome; ischemic stroke; stroke risk score.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Patient selection strategy used in the study. mRS, modified Rankin Scale; mTICI, modified thrombolysis in cerebral infarction.
Figure 2
Figure 2
Receiver operating characteristic curve analyses of unfavorable outcomes based on stroke risk scores. (A) Univariable ROC analysis, (B) multivariable ROC analysis. ROC, receiver operating characteristic.
See this image and copyright information in PMC

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References

    1. Huttner H.B., Schwab S. Malignant middle cerebral artery infarction: Clinical characteristics, treatment strategies, and future perspectives. Lancet Neurol. 2009;8:949–958. doi: 10.1016/S1474-4422(09)70224-8. - DOI - PubMed
    1. Ko S.B., Park H.K., Kim B.M., Heo J.H., Rha J.H., Kwon S.U., Kim J.S., Lee B.C., Suh S.H., Jung C., et al. 2019 Update of the Korean Clinical Practice Guidelines of Stroke for Endovascular Recanalization Therapy in Patients with Acute Ischemic Stroke. J. Stroke. 2019;21:231–240. doi: 10.5853/jos.2019.00024. - DOI - PMC - PubMed
    1. Berkhemer O.A., Fransen P.S., Beumer D., van den Berg L.A., Lingsma H.F., Yoo A.J., Schonewille W.J., Vos J.A., Nederkoorn P.J., Wermer M.J., et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N. Engl. J. Med. 2015;372:11–20. doi: 10.1056/NEJMoa1411587. - DOI - PubMed
    1. Campbell B.C., Mitchell P.J., Kleinig T.J., Dewey H.M., Churilov L., Yassi N., Yan B., Dowling R.J., Parsons M.W., Oxley T.J., et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N. Engl. J. Med. 2015;372:1009–1018. doi: 10.1056/NEJMoa1414792. - DOI - PubMed
    1. Albers G.W., Marks M.P., Kemp S., Christensen S., Tsai J.P., Ortega-Gutierrez S., McTaggart R.A., Torbey M.T., Kim-Tenser M., Leslie-Mazwi T., et al. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging. N. Engl. J. Med. 2018;378:708–718. doi: 10.1056/NEJMoa1713973. - DOI - PMC - PubMed

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