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. 2022 Sep 27;11(19):5708.
doi: 10.3390/jcm11195708.

Survival of Breast Cancer by Stage, Grade and Molecular Groups in Mallorca, Spain

Maria Clara Pascual  1 , Juan José Montaño  1   2 , Paula Franch  2   3 , Carmen Sánchez-Contador  2   3 , Maria Ramos  2   3
Affiliations

Survival of Breast Cancer by Stage, Grade and Molecular Groups in Mallorca, Spain

Maria Clara Pascual et al. J Clin Med. .

Abstract

The aims of this study are: (1) to determine cause-specific survival by stage, grade, and molecular groups of breast cancer, (2) to identify factors which explain and predict the likelihood of survival and the risk of dying from this cancer; and (3) to find out the distribution of breast cancer cases by stage, grade, and molecular groups in females diagnosed in the period 2006-2012 in Mallorca (Spain). We collected data regarding age, date and diagnostic method, histology, laterality, sublocation, pathological or clinical tumor size (T), pathological or clinical regional lymph nodes (N), metastasis (M) and stage, histologic grade, estrogen and progesterone receptors status, HER-2 expression, Ki67 level, molecular classification, date of last follow-up or date of death, and cause of death. We identified 2869 cases. Cause-specific survival for the entire sample was 96% 1 year after diagnosis, 91% at 3 years and 87% at 5 years. Relative survival was 96.9% 1 year after diagnosis, 92.6% at 3 years and 88.5% at 5 years. The competing-risks regression model determined that patients over 65 years of age and patients with triple negative cancer have worse prognoses, and as stages progress, the prognosis for breast cancer worsens, especially from stage III.

Keywords: breast cancer; competing-risks regression model; multiple imputation; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Survival curves of breast cancer by (a) age and (b) histology.
Figure 2
Figure 2
Survival curves of breast cancer by (a) laterality, (b) sublocation, (c) stage, (d) histologic grade and (e) molecular classification, before and after Multiple Imputation (MI) (m = 5).
Figure 2
Figure 2
Survival curves of breast cancer by (a) laterality, (b) sublocation, (c) stage, (d) histologic grade and (e) molecular classification, before and after Multiple Imputation (MI) (m = 5).
See this image and copyright information in PMC

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