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. 2022 Oct 2;14(19):4104.
doi: 10.3390/nu14194104.

Effect of Personalized Nutrition on Dietary, Physical Activity, and Health Outcomes: A Systematic Review of Randomized Trials

Sangeetha Shyam  1   2   3   4 , Ke Xin Lee  5 , Angeline Shu Wei Tan  5 , Tien An Khoo  5 , Shivani Harikrishnan  6 , Shehzeen Alnoor Lalani  7 , Amutha Ramadas  5
Affiliations

Effect of Personalized Nutrition on Dietary, Physical Activity, and Health Outcomes: A Systematic Review of Randomized Trials

Sangeetha Shyam et al. Nutrients. .

Abstract

Personalized nutrition is an approach that tailors nutrition advice to individuals based on an individual's genetic information. Despite interest among scholars, the impact of this approach on lifestyle habits and health has not been adequately explored. Hence, a systematic review of randomized trials reporting on the effects of personalized nutrition on dietary, physical activity, and health outcomes was conducted. A systematic search of seven electronic databases and a manual search resulted in identifying nine relevant trials. Cochrane's Risk of Bias was used to determine the trials' methodological quality. Although the trials were of moderate to high quality, the findings did not show consistent benefits of personalized nutrition in improving dietary, behavioral, or health outcomes. There was also a lack of evidence from regions other than North America and Europe or among individuals with diseases, affecting the generalizability of the results. Furthermore, the complex relationship between genes, interventions, and outcomes may also have contributed to the scarcity of positive findings. We have suggested several areas for improvement for future trials regarding personalized nutrition.

Keywords: nutrigenetics; nutrigenomics; nutrition intervention; personalized nutrition.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA 2020 flow chart showing the study selection process.
Figure 2
Figure 2
Risk of bias summary of included studies (N = 9) [16,17,18,19,20,29,30,31,32].
See this image and copyright information in PMC

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