Silicon-Based Scaffold for Wound Healing Skin Regeneration Applications: A Concise Review

Abstract

Silicon has made its breakthrough in various industries, including clinical and biomedical applications. Silicon-based biomaterials that were fabricated into various types of scaffolds may attract interest due to their highly favorable properties covering their excellent biocompatibility, high surface area, mechanical strength, and selectivity depending on their application including film, hydrogel, nanoparticles, and so on. Silicon-based materials have also shown exciting results involving cell culture, cell growth, as well as tissue engineering. In this article, a simple review compromising the evaluation of silicon's unique properties has been discussed and followed by the application of the silicone-based product in future perspectives in biomedical fields. The review goals are to widen and inspire broader interest in silicone-based materials in wound healing research.

Keywords: silicone; skin regeneration; tissue engineering; wound healing.

Figure 1

Some modifications and use of silicone-based biomaterials to different forms for the application of wound healing, created by Biorender.

Figure 2

The synthesis of silicone redrawn and adopted with some modifications in reference from the image from Odian, G. (2004) [13].

Figure 3

The synthesis of silicon nanoparticles using two different methods. [22]. Used under the Creative Common License.

Figure 4

The mechanism of the action of the silicon nanocarrier delivering antibacterial material towards bacteria [23]. Creative Common Attribution—Non-Commercial (unported, v3.0). Licence (http://creativecommon.org/licenses/by-nc/3.0/, accessed on 1 August 2022).

Figure 5

Application of silicone gel sheeting on top of the wound. The image was redrawn with a slight modification using Illustrator in reference to the figure from Bleasedale et al. [39].

Figure 6

Application and the benefits of silicon-based scaffold on wounds for wound healing treatment.