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. 2022 Oct 6;22(19):7571.
doi: 10.3390/s22197571.

SUDOSCAN, an Innovative, Simple and Non-Invasive Medical Device for Assessing Sudomotor Function

Dana Elena Gavan  1 , Alexandru Gavan  2 , Cosmina Ioana Bondor  3 , Bogdan Florea  1 , Frank Lee Bowling  4   5 , Georgeta Victoria Inceu  6 , Liora Colobatiu  2
Affiliations

SUDOSCAN, an Innovative, Simple and Non-Invasive Medical Device for Assessing Sudomotor Function

Dana Elena Gavan et al. Sensors (Basel). .

Abstract

Diabetic autonomic neuropathy is probably the most undiagnosed but serious complication of diabetes. The main objectives were to assess the prevalence of peripheral and autonomic neuropathy in a population of diabetic patients, analyze it in a real-life outpatient unit scenario and determine the feasibility of performing SUDOSCAN tests together with widely used tests for neuropathy. A total of 33 patients were included in the study. Different scoring systems (the Toronto Clinical Neuropathy Score-TCNS; the Neuropathy Disability Score-NDS; and the Neuropathy Symptom Score-NSS) were applied to record diabetic neuropathy (DN), while the SUDOSCAN medical device was used to assess sudomotor function, detect diabetic autonomic neuropathy and screen for cardiac autonomic neuropathy (CAN). Fifteen (45.5%) patients had sudomotor dysfunction. The SUDOSCAN CAN risk score was positively correlated with the hands' electrochemical sweat conductance (ESC), diastolic blood pressure (DBP), the level of the glycated hemoglobin, as well as with the TCNS, NDS and NSS. Performing SUDOSCAN tests together with other tests for DN proved to be a feasible approach that could be used in daily clinical practice in order to screen for DN, as well as for the early screening of CAN, before more complex and time-consuming tests.

Keywords: SUDOSCAN; cardiac autonomic neuropathy; diabetes mellitus; medical device; sudomotor function.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
SUDOSCAN medical device—general presentation.
Figure 2
Figure 2
CAN risk score estimated by SUDOSCAN and DPN based on TCNS, NDS and NSS. Abbreviations: CAN—cardiac autonomic neuropathy, DPN—diabetic peripheral neuropathy, TCNS—Toronto Clinical Neuropathy Score, NDS—Neuropathy Disability Score, NSS—Neuropathy Symptom Score.
Figure 3
Figure 3
Correlations between the SUDOSCAN CAN risk, hand ESC (a) and TCNS (b). Abbreviations: CAN—cardiac autonomic neuropathy, ESC—electrochemical sweat conductance, TCNS—Toronto Clinical Neuropathy Score.
Figure 4
Figure 4
TCNS in patients found at high and low or no risk for CAN. Abbreviations: CAN—cardiac autonomic neuropathy, TCNS—Toronto Clinical Neuropathy Score.
See this image and copyright information in PMC

References

    1. Mayaudon H., Miloche P.-O., Bauduceau B. A new simple method for assessing sudomotor function: Relevance in type 2 diabetes. Diabetes Metab. 2010;36:450–454. doi: 10.1016/j.diabet.2010.05.004. - DOI - PubMed
    1. Yang Z., Zhang Y., Chen R., Huang Y., Ji L., Sun F., Hong T., Zhan S. Simple tests to screen for diabetic peripheral neuropathy. Cochrane Database Syst. Rev. 2018;2018:CD010975. doi: 10.1002/14651858.CD010975.pub2. - DOI
    1. Boyko E.J., Magliano D.J., Karuranga S., Piemonte L., Riley P., Saeedi P., Sun H., editors. IDF Diabetes Atlas. 10th ed. International Diabetes Federation; Bruxelles, Belgium: 2021.
    1. Ang L., Jaiswal M., Callaghan B., Raffel D., Brown M.B., Pop-Busui R. Sudomotor dysfunction as a measure of small fiber neuropathy in type 1 diabetes. Auton. Neurosci. 2017;205:87–92. doi: 10.1016/j.autneu.2017.03.001. - DOI - PMC - PubMed
    1. Heydari I., Radi V., Razmjou S., Amiri A. Chronic complications of diabetes mellitus in newly diagnosed patients. Int. J. Diabetes Mellit. 2010;2:61–63. doi: 10.1016/j.ijdm.2009.08.001. - DOI

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