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. 2022 Nov 14;40(11):1255-1263.
doi: 10.1016/j.ccell.2022.09.016. Epub 2022 Oct 13.

The therapeutic window of antibody drug conjugates: A dogma in need of revision

Raffaele Colombo  1 , Jamie R Rich  2
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Free article

The therapeutic window of antibody drug conjugates: A dogma in need of revision

Raffaele Colombo et al. Cancer Cell. .
Free article

Abstract

Despite a prevailing dogma wherein antibody drug conjugates (ADCs) increase the maximum tolerated dose of potent cytotoxin payloads while lowering the minimum effective dose, mounting clinical evidence argues that the tolerated doses of ADCs are not significantly different from those of related small molecules. Nonetheless, when dosed at or near the maximum tolerated dose, certain ADCs demonstrate improved efficacy. Understanding the challenges and opportunities for this class of biotherapeutics will help improve the design of next-generation ADCs.

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Conflict of interest statement

Declaration of interests R.C. and J.R.R. are employees and shareholders of Zymeworks Inc. and work to develop antibody drug conjugates for therapeutic applications.

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