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Comment
. 2022 Oct 14;3(10):648-650.
doi: 10.1016/j.medj.2022.09.009.

Somatic genomic mosaicism in the brain: Identified mutations provide challenges and opportunities for the clinic

Jerold Chun  1
Affiliations
Free article
Comment

Somatic genomic mosaicism in the brain: Identified mutations provide challenges and opportunities for the clinic

Jerold Chun. Med. .
Free article

Abstract

Recent work by Bae et al.1 represents a major next-generation sequencing effort to identify somatic genomic mosaicism in normal and diseased human brains. Some samples displayed age-associated hypermutability, and the general possibility that somatic mutations can drive brain disease has implications for new therapeutic strategies, disease staging, biomarkers, and cohort selection for clinical trials.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

  • Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability.
    Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA; Brain Somatic Mosaicism Network§; Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A. Bae T, et al. Science. 2022 Jul 29;377(6605):511-517. doi: 10.1126/science.abm6222. Epub 2022 Jul 28. Science. 2022. PMID: 35901164 Free PMC article.

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