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Review
. 2022 Dec 1;222(Pt B):2744-2760.
doi: 10.1016/j.ijbiomac.2022.10.055. Epub 2022 Oct 12.

Application of hyaluronic acid in tissue engineering, regenerative medicine, and nanomedicine: A review

Kandasamy Saravanakumar  1 , SeonJu Park  2 , Sugavaneswaran Siva Santosh  3 , Archchana Ganeshalingam  4 , Gobika Thiripuranathar  5 , Anbazhagan Sathiyaseelan  6 , Sampathkumar Vijayasarathy  7 , Akila Swaminathan  8 , Veeraraghavan Vishnu Priya  9 , Myeong-Hyeon Wang  10
Affiliations
Review

Application of hyaluronic acid in tissue engineering, regenerative medicine, and nanomedicine: A review

Kandasamy Saravanakumar et al. Int J Biol Macromol. .

Abstract

Hyaluronic acid (HA) plays a vital role in cellular processes and its contribution to physical and immunological barriers is considered to be an important property for the formulation of modern therapeutics. With the increasing demand for non-toxic and targeted therapy, HA-based materials could be utilized for biomedical applications due to their tendency to bio-mimic the hosts. Moreover, HA is a versatile compound in the fabrication of HA-based products such as hydrogels, nanofibers, and 3D materials. These have been implemented in various medical fields, such as bone and tissue regeneration, topical gels for wound healing, and cancer treatment via HA-loaded drug delivery approaches. Herein, we have discussed the characteristics of HA and its significance in drug delivery in addition to synergistic effects with other therapeutic compounds in the fields of nanomedicine, tissue engineering, and regenerative medicine.

Keywords: Drug delivery; Hyaluronic acid; Regenerative medicine; Wound healing.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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