Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Nov;43(11):858-860.
doi: 10.1016/j.it.2022.09.012. Epub 2022 Oct 12.

A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development

Luisa Cervantes-Barragan  1 , Marco Colonna  2
Affiliations
Comment

A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development

Luisa Cervantes-Barragan et al. Trends Immunol. 2022 Nov.

Abstract

CD4+ intraepithelial lymphocytes (CD4IEL) are tissue-resident T cells with cytotoxic and regulatory properties; together with peripheral regulatory T cells, they control intestinal inflammation. Recently, Bousbaine and colleagues identified a microbiota-derived conserved antigen that induces CD4IEL differentiation and promotes their regulatory function, attenuating the severity of murine colitis.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests No competing interest to declare.

Comment on

  • A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes.
    Bousbaine D, Fisch LI, London M, Bhagchandani P, Rezende de Castro TB, Mimee M, Olesen S, Reis BS, VanInsberghe D, Bortolatto J, Poyet M, Cheloha RW, Sidney J, Ling J, Gupta A, Lu TK, Sette A, Alm EJ, Moon JJ, Victora GD, Mucida D, Ploegh HL, Bilate AM. Bousbaine D, et al. Science. 2022 Aug 5;377(6606):660-666. doi: 10.1126/science.abg5645. Epub 2022 Aug 4. Science. 2022. PMID: 35926021 Free PMC article.

Publication types

LinkOut - more resources