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Case Reports
. 2022 Aug 12;21(4):478-483.
doi: 10.18502/ijaai.v21i4.10295.

COVID-19 in Chronic Granulomatosis Disease: A Case Report

Hossein Esmaeilzadeh  1 , Seyed Sina Dehghani  2 , Babak Shahhoseini  3 , Soheila Alyasin  4 , Sayyed Hesamedin Nabavizadeh  5 , Aida Askari  6
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Free article
Case Reports

COVID-19 in Chronic Granulomatosis Disease: A Case Report

Hossein Esmaeilzadeh et al. Iran J Allergy Asthma Immunol. .
Free article

Abstract

A novel coronavirus disease known as Coronavirus Disease 2019 (COVID-19) has spread quickly throughout the world, and it was declared a pandemic in March 2022. Chronic granulomatous disease (CGD) is a diverse group of genetic disorders characterized by recurrent bacterial and fungal infections, resulting in granulomas due to the inability of phagocytes to destroy microbes. Even though it is thought that impaired neutrophil activity is a protective mechanism against severe COVID-19-induced cytokine storms and hyper-inflammatory responses, patients with CGD have normal immunity to most viruses. Here, we present two CGD patients who were hospitalized due to severe COVID-19 infections, which suggests that COVID-19 might have a different pathogenesis than other viruses.

Keywords: Chronic granulomatous disease; Coronavirus disease 2019.

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