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. 2022 Nov;22(11):1538-1540.
doi: 10.1016/S1473-3099(22)00663-6. Epub 2022 Oct 14.

Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies

Daniel J Sheward  1 , Changil Kim  2 , Julian Fischbach  2 , Kenta Sato  2 , Sandra Muschiol  2 , Roy A Ehling  3 , Niklas K Björkström  4 , Gunilla B Karlsson Hedestam  2 , Sai T Reddy  3 , Jan Albert  2 , Thomas P Peacock  5 , Ben Murrell  6
Affiliations

Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies

Daniel J Sheward et al. Lancet Infect Dis. 2022 Nov.
No abstract available

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Conflict of interest statement

STR is a cofounder of and held shares in deepCDR Biologics, which has been acquired by Alloy Therapeutics. DJS, GBKH, and BM have intellectual property rights associated with antibodies that neutralise omicron variants. All other authors declare no competing interests.

Figures

Figure
Figure
BA.2.75.2 escapes neutralising antibodies (A) Differences from BA.2 in BA.2.75 (orange), and BA.2.75.2 (red, underlined), depicted upon the SARS-CoV-2 BA.2 receptor binding domain (pdb:7UB0). Sensitivity of SARS-CoV-2 omicron sublineages and ancestral B.1 (D614G) to neutralisation by monoclonal antibodies (B), and randomly sampled sera from blood donated in Stockholm, Sweden, between Nov 8–14, 2021 (n=25; C), April 11–17, 2022 (n=25; D), and Aug 29 to Sept 4, 2022 (n=25; E). Sera with neutralisation less than 50% at the lowest dilution tested (20) are plotted as 20 (dotted line). IC50=50% inhibitory concentration. ID50=50% inhibitory dilution. *Indicates reversion.
See this image and copyright information in PMC

References

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