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Review
. 2022 Dec;51(4):691-707.
doi: 10.1016/j.ecl.2022.05.002. Epub 2022 Sep 24.

Evaluating Patient-Reported Outcomes in Cushing's Syndrome

Namrata Gumaste  1 , Leena Shah  2 , Khadeen Christi Cheesman  2 , Eliza B Geer  3
Affiliations
Review

Evaluating Patient-Reported Outcomes in Cushing's Syndrome

Namrata Gumaste et al. Endocrinol Metab Clin North Am. 2022 Dec.

Abstract

The importance of the patient's perspective on disease has increasingly gained traction among clinical investigators and clinicians. Patient-reported outcomes (PROs) are those which pertain to a patient's health, quality of life, or functional status (associated with health care or treatment) that are reported directly by the patient, without interpretation by a clinician. In this article, we will review PROs as they relate to the signs, symptoms, health-related quality of life, and comorbidities of active Cushing's syndrome (CS), and CS after treatment with surgery, radiotherapy, and medical therapy. We will explore long-term outcomes in the setting of remission, persistence, and recurrence in this population.

Keywords: Cushing’s disease; Cushing’s syndrome; Patient-reported outcomes; Quality of life.

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Conflict of interest statement

Disclosure E.B. Geer reports serving as an investigator for research grants to MSKCC from Recordati, Strongbridge/Xeris, and Corcept; and serving as an occasional consultant to Xeris. Remaining authors have nothing to disclose.