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Review
. 2022 Dec;51(4):795-815.
doi: 10.1016/j.ecl.2022.06.002.

Physiology of the Weight-Reduced State and Its Impact on Weight Regain

Samar Hafida  1 , Caroline Apovian  2
Affiliations
Review

Physiology of the Weight-Reduced State and Its Impact on Weight Regain

Samar Hafida et al. Endocrinol Metab Clin North Am. 2022 Dec.

Abstract

Obesity is a chronic disease characterized by long duration, slow progression, and periods of remission and relapses. Despite the development of effective medical and surgical interventions and millions of people conducting tremendous personal efforts to manage their weight every year, recidivism remains a significant barrier to attaining long-term weight maintenance. This review aimed to explain the underlying physiology of the weight-reduced state including changes in energy balance, adipose tissue, genetic, environmental, and behavioral factors that may predispose individuals to weight regain following weight loss.

Keywords: Bariatric surgery; Obesity; Pharmacotherapy for obesity management; Physiology of obesity; Weight regain; Weight-reduced state.

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Conflict of interest statement

Disclosure S. Hafida: no disclosure. C. Apovian: Has participated on advisory boards for Altimmune, Inc., Cowen and Company, LLC, Gelesis, Srl., L-Nutra, Inc., NeuroBo Pharmaceuticals, Inc., Novo Nordisk, Inc., Pain Script Corporation, Riverview School, Rhythm Pharmaceuticals, and Xeno Biosciences. Dr C. Apovian has received research funding from the NIH, PCORI and GI Dynamics, Inc.