Comparative Study
doi: 10.1016/0161-4630(78)90076-9.
Prostaglandin-mediated inhibition of noradrenaline release: V. A comparison of the neuroinhibitory effect of three prostaglandins: E2, I2, and 6-keto-PGF1alpha
- PMID: 362453
- DOI: 10.1016/0161-4630(78)90076-9
Item in Clipboard
Comparative Study
Prostaglandin-mediated inhibition of noradrenaline release: V. A comparison of the neuroinhibitory effect of three prostaglandins: E2, I2, and 6-keto-PGF1alpha
Prostaglandins Med.
1978 Jul.
Abstract
The effect of PGE2, PGI2, and 6-keto-PGF1alpha respectively on the contractile response of the isolated, field-stimulated guinea pig vas deferens was investigated. All three PGs were capable of inhibiting the contractile responses of the vas deferens, but the concentrations required varied considerably: PGE2 was about 700 times more active than PGI2 and about 4600 times more active than 6-keto-PGF1alpha in this respect. It is suggested that PGI2, although formed in tissues with sympathetic innervation, does not play a physiological role as inhibitor of sympathetic transmitter release.
Similar articles
-
A comparison of the effects of exogenous and endogenous prostaglandins on fast and slow contractions of field-stimulated guinea-pig vas deferens.Br J Pharmacol. 1995 Nov;116(6):2679-84. doi: 10.1111/j.1476-5381.1995.tb17226.x. Br J Pharmacol. 1995. PMID: 8590989 Free PMC article.
-
Effects of prostaglandin E2, prostaglandin I2 and 6-keto-prostaglandin F1 alpha on adrenergic neurotransmission in the pulmonary artery of the rabbit.Eur J Pharmacol. 1978 Nov 1;52(1):137-41. doi: 10.1016/0014-2999(78)90033-x. Eur J Pharmacol. 1978. PMID: 214309
-
PGE2 is a more potent vasodilator of the lamb ductus arteriosus than is either PGI2 or 6 keto PGF1alpha.Prostaglandins. 1978 Aug;16(2):259-64. doi: 10.1016/0090-6980(78)90028-x. Prostaglandins. 1978. PMID: 360304
-
The influence of prostaglandins on neurotransmission in the rabbit isolated vas deferens.Prostaglandins. 1985 Jan;29(1):47-59. doi: 10.1016/0090-6980(85)90150-9. Prostaglandins. 1985. PMID: 2983376
-
The effects of prostacyclin (PGI2) on tissues which detect prostaglandins (PG'S).Prostaglandins. 1977 Oct;14(4):625-32. doi: 10.1016/0090-6980(77)90189-7. Prostaglandins. 1977. PMID: 339280
Cited by
-
Effect of exogenous and endogenous prostacyclin on the contractility of rabbit splenic capsular smooth muscle.Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312(3):245-53. doi: 10.1007/BF00499154. Naunyn Schmiedebergs Arch Pharmacol. 1980. PMID: 6995863 No abstract available.
-
The effect of indomethacin on the circulatory and plasma noradrenaline responses to cold pressor testing in normal subjects.Clin Auton Res. 1993 Oct;3(5):325-9. doi: 10.1007/BF01827334. Clin Auton Res. 1993. PMID: 8124065 Clinical Trial.
-
Effects of prostacyclin analogue, OP-2507, on function and metabolism in the ischemic working rat heart.J Anesth. 1992 Oct;6(4):446-54. doi: 10.1007/s0054020060446. J Anesth. 1992. PMID: 15278518
-
Regulation of noradrenaline overflow in rat cerebral cortex by prostaglandin E2.Br J Pharmacol. 1980 Nov;70(3):469-73. doi: 10.1111/j.1476-5381.1980.tb08725.x. Br J Pharmacol. 1980. PMID: 6108146 Free PMC article.
-
Effects of thromboxane synthase inhibition on vascular responsiveness in the in vivo rat mesentery.J Clin Invest. 1985 Dec;76(6):2286-95. doi: 10.1172/JCI112238. J Clin Invest. 1985. PMID: 4077980 Free PMC article.