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. 2022 Oct;12(10):e1078.
doi: 10.1002/ctm2.1078.

The status and challenges of optogenetic tools for precise spatiotemporal control of RNA metabolism and function

Renmei Liu  1 , Mengyue Fang  1   2 , Xianjun Chen  1   2 , Yi Yang  1   2
Affiliations

The status and challenges of optogenetic tools for precise spatiotemporal control of RNA metabolism and function

Renmei Liu et al. Clin Transl Med. 2022 Oct.
No abstract available

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Conflict of interest statement

All the authors declare that there is no potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
LicV‐based photoswitchable effectors for spatiotemporal control of RNA metabolism. The synthetic photoswitchable RNA binding protein LicV is fused to various functional domains, including transcriptional activation domain (i), splicing modulatory domain (ii), subcellular localization signal (iii), translation initiation factor (iv), endonuclease domain (v) and other effector domains (vi), for spatiotemporal control of RNA synthesis, splicing, localization, translation, stability and other RNA metabolism, respectively
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