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Review
. 2022 Sep 28:13:988734.
doi: 10.3389/fmicb.2022.988734. eCollection 2022.

The research progress in the interaction between Candida albicans and cancers

Dalang Yu  1 , Zhiping Liu  2
Affiliations
Review

The research progress in the interaction between Candida albicans and cancers

Dalang Yu et al. Front Microbiol. .

Abstract

Candida albicans is an opportunistic pathogenic fungus, which tends to infect the host with defective immune function including cancer patients. A growing number of studies have shown that C. albicans infection increases the host susceptibility to cancer such as oral, gastric, and colorectal cancer. Cancer and anti-cancer treatment may also affect the colonization of C. albicans. C. albicans may promote the development of cancer by damaging mucosal epithelium, inducing the production of carcinogens, triggering chronic inflammation including Th17 cell-mediated immune response. In this article, we aim to elaborate the interaction between C. albicans and cancers development and summarize the potential molecular mechanisms, so as to provide theoretical basis for prevention, diagnosis and treatment of cancers.

Keywords: Candida albicans; cancer; inflammation; interaction; therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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