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. 2022 Sep 28:13:1012025.
doi: 10.3389/fgene.2022.1012025. eCollection 2022.

Frequent cleft lip and palate in families with pathogenic germline CDH1 variants

Benjamin L Green  1 , Grace-Ann Fasaye  2 , Sarah G Samaranayake  1 , Anna Duemler  2 , Lauren A Gamble  1 , Jeremy L Davis  1
Affiliations

Frequent cleft lip and palate in families with pathogenic germline CDH1 variants

Benjamin L Green et al. Front Genet. .

Abstract

Pathogenic and likely pathogenic (P/LP) germline variants in the tumor suppressor gene CDH1 (E-cadherin) result in increased lifetime risk of diffuse-type gastric cancer and lobular breast cancer. CDH1 variants are also associated with hereditary cleft lip and palate (CLP), the mechanism of which is not well understood. We sought to determine the prevalence of CLP in families who carry P/LP CDH1 variants. Patients with P/LP CDH1 variants who were enrolled in a prospective clinical trial were reviewed (NCT03030404). The cohort included 299 individuals from 153 families that had 80 unique P/LP variants in CDH1. The rate of CLP was 19% (29/153) in families reporting CLP in at least one family member, and 2.7% (8/299) among individuals with confirmed germline CDH1 P/LP variants. There were 22 unique variants in CDH1 among the 29 families that reported CLP, or a CLP rate of 27.5% per variant (22/80). 10 of the variants were not previously reported to be associated with CLP. We observed that 24% (7/29) of CLP-associated gene variants involved large-scale (≥1 exon) deletions. Among families with CLP, 69% (20/29) had a member diagnosed with gastric cancer, and 79% (23/29) had a member with breast cancer, which were similar to rates observed in non-CLP families (p >0.3 for both). Our analysis suggests that the prevalence of CLP in families with germline CDH1 P/LP variants was high in this large cohort, and there was no genotype-phenotype pattern. Genetic testing for CDH1 variants should be considered in families with CLP and history of either diffuse-type gastric or lobular breast cancer.

Keywords: CDH1; E-cadherin; cleft lip; cleft lip/palate; cleft palate; hereditary diffuse gastric cancer syndrome.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Map of variants in CDH1 for patients reporting family history of CLP.
See this image and copyright information in PMC

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