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. 2022 Sep 29:35:10656.
doi: 10.3389/ti.2022.10656. eCollection 2022.

Combined Donor-Recipient Obesity and the Risk of Graft Loss After Kidney Transplantation

Faisal Jarrar  1 , Karthik K Tennankore  1   2 , Amanda J Vinson  1   2
Affiliations

Combined Donor-Recipient Obesity and the Risk of Graft Loss After Kidney Transplantation

Faisal Jarrar et al. Transpl Int. .

Abstract

Background: As the prevalence of obesity increases globally, appreciating the effect of donor and recipient (DR) obesity on graft outcomes is of increasing importance. Methods: In a cohort of adult, kidney transplant recipients (2000-2017) identified using the SRTR, we used Cox proportional hazards models to examine the association between DR obesity pairing (body mass index (BMI) >30 kg/m2), and death-censored graft loss (DCGL) or all-cause graft loss, and logistic regression to examine risk of delayed graft function (DGF) and ≤30 days graft loss. We also explored the association of DR weight mismatch (>30 kg, 10-30 kg (D>R; D<R) and <10 kg (D = R)) with each outcome, stratifying by DR obesity pairing. Results: Relative to non-obese DR, obese DR were highest risk for all outcomes (DCGL: HR 1.26, 95% CI 1.22-1.32; all-cause graft loss: HR 1.09, 95% CI 1.06-1.12; DGF: OR 1.98, 95% CI 1.89-2.08; early graft loss: OR 1.34, 95% CI 1.19-1.51). Donor obesity modified the risk of recipient obesity and DCGL [p = 0.001] and all-cause graft loss [p < 0.001] but not DGF or early graft loss. The known association of DR weight mismatch with DCGL was attenuated when either the donor or recipient was obese. Conclusion: DR obesity status impacts early and late post-transplant outcomes.

Keywords: body mass index; graft loss; kidney transplant outcomes; obesity; obesity pairing; weight mismatch.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Final study cohort following exclusions.
FIGURE 2
FIGURE 2
Temporal changes in donor-recipient obesity pairing over time. The accompanying table displays descriptive statistics for each of the donor-recipient obesity pairings.
FIGURE 3
FIGURE 3
Kaplan-Meier survival curves for time to death-censored graft loss for each donor-recipient obesity pairing. A number at risk table is included below the figure. *The log-rank p-value is <0.001.
FIGURE 4
FIGURE 4
Hazard ratio plot for death-censored graft loss for combined donor-recipient weight mismatch, stratified by donor-recipient obesity. Models were adjusted for known literature predictors of graft loss, including donor and recipient age, race, sex, recipient end-stage kidney disease (ESKD) cause, cold ischemia time (CIT), dialysis vintage, pre-emptive status, previous kidney transplant, human leukocyte antigen (HLA) mismatch, peak panel reactive antibody (PRA), and recipient medical comorbidities (coronary artery disease, hypertension, peripheral vascular disease, type 2 diabetes).
See this image and copyright information in PMC

References

    1. Prospective Studies Collaboration, Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, et al. Body-mass index and Cause-specific Mortality in 900 000 Adults: Collaborative Analyses of 57 Prospective Studies. Lancet (2009) 373:1083–96. 10.1016/S0140-6736(09)60318-4 - DOI - PMC - PubMed
    1. Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017–2018. Natl Cent Health Stat (2020) 360. - PubMed
    1. Friedman AN, Miskulin DC, Rosenberg IH, Levey AS. Demographics and Trends in Overweight and Obesity in Patients at Time of Kidney Transplantation. Am J Kidney Dis (2003) 41:480–7. 10.1053/ajkd.2003.50059 - DOI - PubMed
    1. García-Carro C, Vergara A, Bermejo S, Azancot MA, Sellarés J, Soler MJ. A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management. Front Med (2021) 8:655871. 10.3389/fmed.2021.655871 - DOI - PMC - PubMed
    1. Oniscu GC, Abramowicz D, Bolignano D, Gandolfini I, Hellemans R, Maggiore U, et al. Management of Obesity in Kidney Transplant Candidates and Recipients: A Clinical Practice Guideline by the DESCARTES Working Group of ERA. Nephrol Dial Transpl (2021) 37:i1–i15. 10.1093/ndt/gfab310 - DOI - PMC - PubMed