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Case Reports
. 2022 Summer;17(3):371-375.
doi: 10.30699/IJP.2022.542788.2766. Epub 2021 Aug 14.

A Young Iranian Woman with Pure Primary Ovarian Neuroendocrine Tumor: A Case Report

Fatemeh Samiee-Rad  1 , Mahdi Ghaebi  1 , Arezoo Bajelan  1
Affiliations
Case Reports

A Young Iranian Woman with Pure Primary Ovarian Neuroendocrine Tumor: A Case Report

Fatemeh Samiee-Rad et al. Iran J Pathol. 2022 Summer.

Abstract

Pure ovarian neuroendocrine tumors are very rare. Herein, we present a young Iranian woman with a pure primary ovarian neuroendocrine tumor. A 26-year-old female presented with chronic abdominal pain and progressive constipation and was referred to the emergency room. Imaging findings confirmed a mass in the right adnexa. Following the resectional surgery of the ovarian mass, histopathological and immunohistochemistry results disclosed a mixed type of primary ovarian neuroendocrine tumor. The patient did not experience tumor recurrence afterward. Due to the rarity and low prevalence of primary pure ovarian neuroendocrine tumors, the histopathologic diagnosis should be confirmed by an immunohistochemistry study.

Keywords: Neuroendocrine neoplasm; Neuroendocrine tumor; Ovary; Primary; Pure.

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Conflict of interest statement

The authors declared no conflicts of interest.

Figures

Fig. 1
Fig. 1
Postoperative view of the right adnexum revealed an encapsulated mass. Cut sections showed homogenous creamy - gray- yellow soft tissue with hemorrhage
Fig. 2
Fig. 2
A: Histopathologic findings of ovarian neuroendocrine tumor in insular, trabecular, stromal and small acini growth pattern. B: Individual tumoral cells with neuroendocrine nuclear properties, eosinophilic cytoplasm and distinct cell borders. 100 (A), 400 (B), Hematoxylin & Eosin stain
Fig. 3
Fig. 3
Nuclear immunoexpression of Ki67 in primary ovarian neuroendocrine tumor, < 3%. 400 , IHC stain
Fig. 4.
Fig. 4.
A: Granular cytoplasmic immunoexpression of chromogranin in primary ovarian neuroendocrine tumor. B: Nuclear expression of PAX8 in primary ovarian neuroendocrine tumor. 400 , IHC stain
See this image and copyright information in PMC

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