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Review
. 2022 Sep 29:10:1013670.
doi: 10.3389/fchem.2022.1013670. eCollection 2022.

Natural products targeting human lactate dehydrogenases for cancer therapy: A mini review

Huankai Yao  1 , Feng Yang  2 , Yan Li  1
Affiliations
Review

Natural products targeting human lactate dehydrogenases for cancer therapy: A mini review

Huankai Yao et al. Front Chem. .

Abstract

Reprogramming cancer metabolism has become the hallmark of cancer progression. As the key enzyme catalyzing the conversion of pyruvate to lactate in aerobic glycolysis of cancer cells, human lactate dehydrogenase (LDH) has been a promising target in the discovery of anticancer agents. Natural products are important sources of new drugs. Up to now, some natural compounds have been reported with the activity to target LDH. To give more information on the development of LDH inhibitors and application of natural products, herein, we reviewed the natural compounds with inhibition of LDH from diverse structures and discussed the future direction of the discovery of natural LDH inhibitors for cancer therapy.

Keywords: Warburg effect; cancer metabolism; inhibitors; lactate dehydrogenase; natural products.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The Warburg effect and lactate dehydrogenase. (A) The Warburg effect. (B) Reaction catalyzed by LDH. (C) Isoforms of LDH. (D) Structure of LDH5 with the binding mode of NADH (PDB code 1I10). Four monomers (LDHA) were rendered with magenta, cyan, green, and yellow, respectively. Active site loop was highlighted in blue. NADH was shown as sticks.
FIGURE 2
FIGURE 2
Natural products with potential inhibition of LDH.
See this image and copyright information in PMC

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