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. 2022 Oct;39(4):1117-1125.
doi: 10.5114/biolsport.2023.118336. Epub 2022 Sep 5.

The effect of IL10 gene polymorphism on obesity parameters in highly physically active young men

Ewelina Maculewicz  1 , Andrzej Mastalerz  1 , Bożena Antkowiak  2 , Oktawiusz Antkowiak  2 , Aleksandra Garbacz  3 , Ewa Szarska  2 , Paweł Rusin  4 , Anna Cywińska  5 , Agnieszka Białek  6 , Paweł Cięszczyk  7
Affiliations

The effect of IL10 gene polymorphism on obesity parameters in highly physically active young men

Ewelina Maculewicz et al. Biol Sport. 2022 Oct.

Abstract

The main aim of this study was to investigate the association between 5 polymorphisms of the interleukin 10 (IL10) gene and body composition parameters in physically active young men. A cohort of 131 young men was enrolled and the following IL10 single-nucleotide polymorphisms (SNPs) were analysed: rs1518111, rs1878672, rs3024496, rs3024498 and rs3024505. The subjects were divided into groups depending on obesity parameters: body mass index (BMI) and percentage of body fat tissue (fat %). Statistical analysis was conducted for alleles, genotypes and haplotypes, and an association between SNPs and body composition parameters was analysed using four genetic models: dominant, recessive, codominant and overdominant mode of inheritance (MOI). The only statistically significant result in polymorphisms was found for rs3024505 in the over-dominant model with BMI (p = 0.04) and with fat % (p = 0.02). The haplo.score function showed an association between BMI and CCGTA (respectively) haplotype in the additive model (score = -2.00, p = 0.04) and in the dominant model (score = -2.30, p = 0.02). The obtained results indicate a statistically significant contribution of selected IL10 polymorphisms in the regulation of body weight in physically active individuals.

Keywords: BMI; Fat percentage; Genetic polymorphisms; Haplotype; IL10; Interleukin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIG. 1
FIG. 1
IL10 gene (Chromosome 1).
See this image and copyright information in PMC

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