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Review
. 2022 Sep 29:14:987732.
doi: 10.3389/fnagi.2022.987732. eCollection 2022.

Non-invasive brain stimulation for osteoarthritis

Hui-Qi Zhu  1   2 , Jing Luo  3 , Xue-Qiang Wang  2   4 , Xin-An Zhang  1
Affiliations
Review

Non-invasive brain stimulation for osteoarthritis

Hui-Qi Zhu et al. Front Aging Neurosci. .

Abstract

Osteoarthritis (OA) is a degenerative joint disease, the prevalence of OA is increasing, and the elderly are the most common in patients with OA. OA has a severe impact on the daily life of patients, this increases the demand for treatment of OA. In recent years, the application of non-invasive brain stimulation (NIBS) has attracted extensive attention. It has been confirmed that NIBS plays an important role in regulating cortical excitability and oscillatory rhythm in specific brain regions. In this review, we summarized the therapeutic effects and mechanisms of different NIBS techniques in OA, clarified the potential of NIBS as a treatment choice for OA, and provided prospects for further research in the future.

Keywords: NIBS; osteoarthritis; rTMS; single-pulse TMS; tACS; tDCS; tFUS; tRNS.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) Publications accumulated by year. (B) From 1990 to 2020, publications were classified annually in accordance with different non-invasive brain stimuli in categories that included repetitive transcranial magnetic stimulation (rTMS, orange), single-pulse transcranial magnetic stimulation (single-pulse TMS, blue), transcranial direct current stimulation (tDCS, gray), transcranial alternating current stimulation (tACS, yellow), transcranial random noise stimulation (tRNS, light blue), and transcranial focused ultrasound stimulation (tFUS, green).
FIGURE 2
FIGURE 2
Six major non-invasive brain stimuli and their site of action. rTMS generally functions in the dorsolateral PFC (DLPFC) (Lefaucheur et al., 2020). Single-pulse TMS uses frequent sites of action, such as the primary motor cortex (M1) (Savoie et al., 2020). tDCS and tACS cathode and anode positions: contralateral orbit (SO), primary sensory cortex (S1) (Marlow et al., 2013; May et al., 2021). tRNS: cerebral cortex. tFUS: thalamus (Th) (Palm et al., 2016b; Badran et al., 2020).
FIGURE 3
FIGURE 3
Picture showing the likely mechanism of action of different forms of NIBS in the treatment of osteoarthritis.
FIGURE 4
FIGURE 4
Effects of six major NIBS on OA.
See this image and copyright information in PMC

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