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. 2022 May 19;12(3):312-316.
doi: 10.4103/tjo.tjo_12_22. eCollection 2022 Jul-Sep.

Incidence and association of ocular manifestations with the disease severity in COVID-19 patients of northern region of India

Aalok Kumar  1 , Lavanya Anuranjani  2
Affiliations

Incidence and association of ocular manifestations with the disease severity in COVID-19 patients of northern region of India

Aalok Kumar et al. Taiwan J Ophthalmol. .

Abstract

Purpose: Our study aims to find the incidence of ocular manifestations and to investigate the relation of ocular manifestations with the disease severity among coronavirus disease 2019 (COVID-19) patients.

Material and methods: Our study is a cross-sectional study done between May 15, 2020, and April 15, 2021, at Hind Institute of Medical Sciences, Lucknow, India. All COVID-19 patients who got admitted to our center between May 15, 2020, and April 15, 2021, were included in our study. We included 261 patients in our study. Diagnosis of COVID-19 was made by testing the nasal and pharyngeal swabs by (reverse transcriptase-polymerase chain reaction [RT-PCR]). An RT-PCR test positive was the criteria for admission in the COVID ward. Statistical analyses were performed using the Mann-Whitney U-test, Chi-square test, and Kolmogorov-Smirnov test. P < 0.01 was considered statistically significant.

Results: We included 261 patients in our study. Out of 261 patients, ocular manifestations were found in 43 (16.4%) patients. The patients with ocular manifestations had higher neutrophil counts, erythrocyte sedimentation rate (ESR), procalcitonin (PCT), C-reactive protein (CRP), and D-dimer values (P < 0.001). Patients with ocular manifestations were relatively more symptomatic concerning fever and myalgia.

Conclusion: The incidence of ocular manifestations in COVID-19 patients was 16.4%. Ocular manifestation was significantly associated with raised neutrophil counts, CRP, ESR, PCT, and D-dimer values. Ocular manifestation was also significantly associated with higher body temperature and higher mean age. The findings of the study are suggestive of more severe disease in patients of COVID-19 with ocular manifestations.

Keywords: C-reactive protein; Conjunctivitis; coronavirus disease 2019; erythrocytic sedimentation rate; red eye.

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Conflict of interest statement

The authors declare that there are no conflicts of interests of this paper.

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References

    1. Callaway E, Cyranoski D. New China virus: Five questions scientists are asking. Nature. 2020;577:7792. - PubMed
    1. Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 2020;395:470–3. - PMC - PubMed
    1. Organization WH. Infection Prevention and Control During Health Care When Novel Coronavirus (nCoV) Infection is Suspected: Interim Guidance, January 2020. World Health Organization; 2020.
    1. Corman VM, Muth D, Niemeyer D, Drosten C. Hosts and sources of endemic human coronaviruses. Adv Virus Res. 2018;100:163–88. - PMC - PubMed
    1. Loon S, Teoh S, Oon L, Se-Thoe S, Ling A, Leo Y, et al. The severe acute respiratory syndrome coronavirus in tears. Br J Ophthalmol. 2004;88:861–3. - PMC - PubMed