doi: 10.1016/j.bas.2021.100854.
eCollection 2022.
Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury
Collaborators,
Affiliations
Collaborators
-
CENTER-TBI investigators and participants:
Cecilia Åkerlund 7 , Krisztina Amrein 8 , Nada Andelic 9 , Lasse Andreassen 10 , Audny Anke 11 , Anna Antoni 12 , Gérard Audibert 13 , Philippe Azouvi 14 , Maria Luisa Azzolini 15 , Ronald Bartels 16 , Pál Barzó 17 , Romuald Beauvais 18 , Ronny Beer 19 , Bo-Michael Bellander 20 , Antonio Belli 21 , Habib Benali 22 , Maurizio Berardino 23 , Luigi Beretta 15 , Morten Blaabjerg 24 , Peter Bragge 25 , Alexandra Brazinova 26 , Vibeke Brinck 27 , Joanne Brooker 28 , Camilla Brorsson 29 , Andras Buki 30 , Monika Bullinger 31 , Manuel Cabeleira 32 , Alessio Caccioppola 33 , Emiliana Calappi 33 , Maria Rosa Calvi 15 , Peter Cameron 34 , Guillermo Carbayo Lozano 35 , Marco Carbonara 33 , Simona Cavallo 23 , Giorgio Chevallard 36 , Arturo Chieregato 36 , Giuseppe Citerio 37 38 , Iris Ceyisakar 39 , Hans Clusmann 40 , Mark Coburn 41 , Jonathan Coles 42 , Jamie D Cooper 34 , Marta Correia 43 , Amra Čović 44 , Nicola Curry 45 , Endre Czeiter 30 , Marek Czosnyka 32 , Claire Dahyot-Fizelier 46 , Paul Dark 47 , Helen Dawes 48 , Véronique De Keyser 49 , Vincent Degos 22 , Francesco Della Corte 50 , Hugo den Boogert 16 , Bart Depreitere 51 , Đula Đilvesi 52 , Abhishek Dixit 53 , Emma Donoghue 28 , Jens Dreier 54 , Guy-Loup Dulière 55 , Ari Ercole 53 , Patrick Esser 48 , Erzsébet Ezer 56 , Martin Fabricius 57 , Valery L Feigin 58 , Kelly Foks 59 , Shirin Frisvold 60 , Alex Furmanov 61 , Pablo Gagliardo 62 , Damien Galanaud 22 , Dashiell Gantner 63 , Guoyi Gao 64 , Pradeep George 65 , Alexandre Ghuysen 66 , Lelde Giga 67 , Ben Glocker 68 , Jagoš Golubovic 52 , Pedro A Gomez 69 , Johannes Gratz 70 , Benjamin Gravesteijn 39 , Francesca Grossi 50 , Russell L Gruen 71 , Deepak Gupta 72 , Juanita A Haagsma 39 , Iain Haitsma 73 , Raimund Helbok 19 , Eirik Helseth 74 , Lindsay Horton 75 , Jilske Huijben 39 , Peter J Hutchinson 76 , Bram Jacobs 77 , Stefan Jankowski 78 , Mike Jarrett 27 , Ji-Yao Jiang 64 , Faye Johnson 79 , Kelly Jones 58 , Mladen Karan 52 , Angelos G Kolias 76 , Erwin Kompanje 77 , Daniel Kondziella 57 , Evgenios Koraropoulos 53 , Lars-Owe Koskinen 80 , Noémi Kovács 81 , Ana Kowark 41 , Alfonso Lagares 69 , Linda Lanyon 65 , Steven Laureys 82 , Fiona Lecky 83 84 , Didier Ledoux 82 , Rolf Lefering 85 , Valerie Legrand 86 , Aurelie Lejeune 87 , Leon Levi 88 , Roger Lightfoot 89 , Hester Lingsma 39 , Andrew Ir Maas 49 , Ana M Castaño-León 69 , Marc Maegele 90 , Marek Majdan 26 , Alex Manara 91 , Geoffrey Manley 92 , Costanza Martino 93 , Hugues Maréchal 55 , Julia Mattern 94 , Catherine McMahon 95 , Béla Melegh 96 , David Menon 53 , Tomas Menovsky 49 , Ana Mikolic 39 , Benoit Misset 82 , Visakh Muraleedharan 65 , Lynnette Murray 63 , Ancuta Negru 97 , David Nelson 7 , Virginia Newcombe 53 , Daan Nieboer 39 , József Nyirádi 8 , Otesile Olubukola 83 , Matej Oresic 98 , Fabrizio Ortolano 33 , Aarno Palotie 99 100 101 , Paul M Parizel 102 , Jean-François Payen 103 , Natascha Perera 18 , Vincent Perlbarg 22 , Paolo Persona 104 , Wilco Peul 105 , Anna Piippo-Karjalainen 106 , Matti Pirinen 99 , Horia Ples 97 , Suzanne Polinder 39 , Inigo Pomposo 35 , Jussi P Posti 107 , Louis Puybasset 108 , Andreea Radoi 109 , Arminas Ragauskas 110 , Rahul Raj 106 , Malinka Rambadagalla 111 , Jonathan Rhodes 112 , Sylvia Richardson 113 , Sophie Richter 53 , Samuli Ripatti 99 , Saulius Rocka 110 , Cecilie Roe 114 , Olav Roise 115 116 , Jonathan Rosand 117 , Jeffrey V Rosenfeld 118 , Christina Rosenlund 119 , Guy Rosenthal 61 , Rolf Rossaint 41 , Sandra Rossi 104 , Daniel Rueckert 68 , Martin Rusnák 120 , Juan Sahuquillo 109 , Oliver Sakowitz 94 121 , Renan Sanchez-Porras 121 , Janos Sandor 122 , Nadine Schäfer 85 , Silke Schmidt 123 , Herbert Schoechl 124 , Guus Schoonman 125 , Rico Frederik Schou 126 , Elisabeth Schwendenwein 12 , Charlie Sewalt 39 , Toril Skandsen 127 128 , Peter Smielewski 32 , Abayomi Sorinola 129 , Emmanuel Stamatakis 53 , Simon Stanworth 45 , Robert Stevens 130 , William Stewart 131 , Ewout W Steyerberg 39 132 , Nino Stocchetti 133 , Nina Sundström 134 , Anneliese Synnot 28 135 , Riikka Takala 136 , Viktória Tamás 129 , Tomas Tamosuitis 137 , Mark Steven Taylor 26 , Braden Te Ao 58 , Olli Tenovuo 107 , Alice Theadom 58 , Matt Thomas 91 , Dick Tibboel 138 , Marjolein Timmers 139 , Christos Tolias 140 , Tony Trapani 63 , Cristina Maria Tudora 97 , Andreas Unterberg 94 , Peter Vajkoczy 141 , Shirley Vallance 63 , Egils Valeinis 67 , Zoltán Vámos 56 , Mathieu van der Jagt 142 , Gregory Van der Steen 49 , Joukje van der Naalt 77 , Jeroen Tjm van Dijck 105 , Thomas A van Essen 105 , Wim Van Hecke 143 , Caroline van Heugten 48 , Dominique Van Praag 144 , Thijs Vande Vyvere 143 , Roel Pj van Wijk 105 , Alessia Vargiolu 38 , Emmanuel Vega 87 , Kimberley Velt 39 , Jan Verheyden 143 , Paul M Vespa 145 , Anne Vik 127 146 , Rimantas Vilcinis 137 , Victor Volovici 73 , Nicole von Steinbüchel 44 , Daphne Voormolen 39 , Petar Vulekovic 52 , Kevin Kw Wang 147 , Eveline Wiegers 39 , Guy Williams 53 , Lindsay Wilson 75 , Stefan Winzeck 53 , Stefan Wolf 148 , Zhihui Yang 147 , Peter Ylén 149 , Alexander Younsi 94 , Frederick A Zeiler 53 150 , Veronika Zelinkova 26 , Agate Ziverte 67 , Tommaso Zoerle 33
Affiliations
- 1 Department of Psychology, Antwerp University Hospital, Edegem and University of Antwerp, Antwerp, Belgium.
- 2 Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Drie Eikenstraat 655, 2650, Edegem, Belgium.
- 3 Clinical Trial Centre (CTC), CRC Antwerp, Antwerp University Hospital, Edegem and University of Antwerp, Antwerp, Belgium.
- 4 Department of Psychiatry, Antwerp University Hospital, Drie Eikenstraat 655, 2650, Edegem, Belgium.
- 5 Division of Psychology, University of Stirling, Stirling, FK9 4LA, United Kingdom.
- 6 Department of Neurosurgery, Antwerp University Hospital, Edegem and University of Antwerp, Drie Eikenstraat 655, 2650, Edegem, Belgium.
- 7 Department of Physiology and Pharmacology, Section of Perioperative Medicine and Intensive Care, Karolinska Institutet, Stockholm, Sweden.
- 8 János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
- 9 Division of Surgery and Clinical Neuroscience, Department of Physical Medicine and Rehabilitation, Oslo University Hospital and University of Oslo, Oslo, Norway.
- 10 Department of Neurosurgery, University Hospital Northern Norway, Tromso, Norway.
- 11 Department of Physical Medicine and Rehabilitation, University Hospital Northern Norway, Tromso, Norway.
- 12 Trauma Surgery, Medical University Vienna, Vienna, Austria.
- 13 Department of Anesthesiology & Intensive Care, University Hospital Nancy, Nancy, France.
- 14 Raymond Poincare Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.
- 15 Department of Anesthesiology & Intensive Care, S Raffaele University Hospital, Milan, Italy.
- 16 Department of Neurosurgery, Radboud University Medical Center, Nijmegen, the Netherlands.
- 17 Department of Neurosurgery, University of Szeged, Szeged, Hungary.
- 18 International Projects Management, ARTTIC, Munchen, Germany.
- 19 Department of Neurology, Neurological Intensive Care Unit, Medical University of Innsbruck, Innsbruck, Austria.
- 20 Department of Neurosurgery & Anesthesia & Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden.
- 21 NIHR Surgical Reconstruction and Microbiology Research Centre, Birmingham, UK.
- 22 Anesthesie-Réanimation, Assistance Publique - Hopitaux de Paris, Paris, France.
- 23 Department of Anesthesia & ICU, AOU Città della Salute e della Scienza di Torino - Orthopedic and Trauma Center, Torino, Italy.
- 24 Department of Neurology, Odense University Hospital, Odense, Denmark.
- 25 BehaviourWorks Australia, Monash Sustainability Institute, Monash University, Victoria, Australia.
- 26 Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovakia.
- 27 Quesgen Systems Inc., Burlingame, CA, USA.
- 28 Australian & New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
- 29 Department of Surgery and Perioperative Science, Umeå University, Umeå, Sweden.
- 30 Department of Neurosurgery, Medical School, University of Pécs, Hungary and Neurotrauma Research Group, János Szentágothai Research Centre, University of Pécs, Hungary.
- 31 Department of Medical Psychology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
- 32 Brain Physics Lab, Division of Neurosurgery, Dept of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
- 33 Neuro ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
- 34 School of Public Health & PM, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia.
- 35 Department of Neurosurgery, Hospital of Cruces, Bilbao, Spain.
- 36 NeuroIntensive Care, Niguarda Hospital, Milan, Italy.
- 37 School of Medicine and Surgery, Università Milano Bicocca, Milano, Italy.
- 38 NeuroIntensive Care, ASST di Monza, Monza, Italy.
- 39 Department of Public Health, Erasmus Medical Center-University Medical Center, Rotterdam, the Netherlands.
- 40 Department of Neurosurgery, Medical Faculty RWTH Aachen University, Aachen, Germany.
- 41 Department of Anaesthesiology, University Hospital of Aachen, Aachen, Germany.
- 42 Department of Anesthesia & Neurointensive Care, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.
- 43 Radiology/MRI department, MRC Cognition and Brain Sciences Unit, Cambridge, UK.
- 44 Institute of Medical Psychology and Medical Sociology, Universitätsmedizin Göttingen, Göttingen, Germany.
- 45 Oxford University Hospitals NHS Trust, Oxford, UK.
- 46 Intensive Care Unit, CHU Poitiers, Potiers, France.
- 47 University of Manchester NIHR Biomedical Research Centre, Critical Care Directorate, Salford Royal Hospital NHS Foundation Trust, Salford, UK.
- 48 Movement Science Group, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
- 49 Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium.
- 50 Department of Anesthesia & Intensive Care, Maggiore Della Carità Hospital, Novara, Italy.
- 51 Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.
- 52 Department of Neurosurgery, Clinical Centre of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
- 53 Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
- 54 Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, And Berlin Institute of Health, Berlin, Germany.
- 55 Intensive Care Unit, CHR Citadelle, Liège, Belgium.
- 56 Department of Anaesthesiology and Intensive Therapy, University of Pécs, Pécs, Hungary.
- 57 Departments of Neurology, Clinical Neurophysiology and Neuroanesthesiology, Region Hovedstaden Rigshospitalet, Copenhagen, Denmark.
- 58 National Institute for Stroke and Applied Neurosciences, Faculty of Health and Environmental Studies, Auckland University of Technology, Auckland, New Zealand.
- 59 Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
- 60 Department of Anesthesiology and Intensive Care, University Hospital Northern Norway, Tromso, Norway.
- 61 Department of Neurosurgery, Hadassah-hebrew University Medical Center, Jerusalem, Israel.
- 62 Fundación Instituto Valenciano de Neurorrehabilitación (FIVAN), Valencia, Spain.
- 63 ANZIC Research Centre, Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Victoria, Australia.
- 64 Department of Neurosurgery, Shanghai Renji Hospital, Shanghai Jiaotong University/school of Medicine, Shanghai, China.
- 65 Karolinska Institutet, INCF International Neuroinformatics Coordinating Facility, Stockholm, Sweden.
- 66 Emergency Department, CHU, Liège, Belgium.
- 67 Neurosurgery Clinic, Pauls Stradins Clinical University Hospital, Riga, Latvia.
- 68 Department of Computing, Imperial College London, London, UK.
- 69 Department of Neurosurgery, Hospital Universitario 12 de Octubre, Madrid, Spain.
- 70 Department of Anesthesia, Critical Care and Pain Medicine, Medical University of Vienna, Austria.
- 71 College of Health and Medicine, Australian National University, Canberra, Australia.
- 72 Department of Neurosurgery, Neurosciences Centre & JPN Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, 110029, India.
- 73 Department of Neurosurgery, Erasmus MC, Rotterdam, the Netherlands.
- 74 Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.
- 75 Division of Psychology, University of Stirling, Stirling, UK.
- 76 Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital & University of Cambridge, Cambridge, UK.
- 77 Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 78 Neurointensive Care, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
- 79 Salford Royal Hospital NHS Foundation Trust Acute Research Delivery Team, Salford, UK.
- 80 Department of Clinical Neuroscience, Neurosurgery, Umeå University, Umeå, Sweden.
- 81 Hungarian Brain Research Program - Grant No. KTIA_13_NAP-A-II/8, University of Pécs, Pécs, Hungary.
- 82 Cyclotron Research Center, University of Liège, Liège, Belgium.
- 83 Centre for Urgent and Emergency Care Research (CURE), Health Services Research Section, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
- 84 Emergency Department, Salford Royal Hospital, Salford, UK.
- 85 Institute of Research in Operative Medicine (IFOM), Witten/Herdecke University, Cologne, Germany.
- 86 VP Global Project Management CNS, ICON, Paris, France.
- 87 Department of Anesthesiology-Intensive Care, Lille University Hospital, Lille, France.
- 88 Department of Neurosurgery, Rambam Medical Center, Haifa, Israel.
- 89 Department of Anesthesiology & Intensive Care, University Hospitals Southhampton NHS Trust, Southhampton, UK.
- 90 Cologne-Merheim Medical Center (CMMC), Department of Traumatology, Orthopedic Surgery and Sportmedicine, Witten/Herdecke University, Cologne, Germany.
- 91 Intensive Care Unit, Southmead Hospital, Bristol, Bristol, UK.
- 92 Department of Neurological Surgery, University of California, San Francisco, CA, USA.
- 93 Department of Anesthesia & Intensive Care,M. Bufalini Hospital, Cesena, Italy.
- 94 Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
- 95 Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.
- 96 Department of Medical Genetics, University of Pécs, Pécs, Hungary.
- 97 Department of Neurosurgery, Emergency County Hospital Timisoara, Timisoara, Romania.
- 98 School of Medical Sciences, Örebro University, Örebro, Sweden.
- 99 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
- 100 Analytic and Translational Genetics Unit, Department of Medicine, Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
- 101 Program in Medical and Population Genetics, The Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 102 Department of Radiology, University of Antwerp, Edegem, Belgium.
- 103 Department of Anesthesiology & Intensive Care, University Hospital of Grenoble, Grenoble, France.
- 104 Department of Anesthesia & Intensive Care, Azienda Ospedaliera Università di Padova, Padova, Italy.
- 105 Dept. of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands and Dept. of Neurosurgery, Medical Center Haaglanden, The Hague, the Netherlands.
- 106 Department of Neurosurgery, Helsinki University Central Hospital, Finland.
- 107 Division of Clinical Neurosciences, Department of Neurosurgery and Turku Brain Injury Centre, Turku University Hospital and University of Turku, Turku, Finland.
- 108 Department of Anesthesiology and Critical Care, Pitié -Salpêtrière Teaching Hospital, Assistance Publique, Hôpitaux de Paris and University Pierre et Marie Curie, Paris, France.
- 109 Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d'Hebron Research Institute, Barcelona, Spain.
- 110 Department of Neurosurgery, Kaunas University of Technology and Vilnius University, Vilnius, Lithuania.
- 111 Department of Neurosurgery, Rezekne Hospital, Latvia.
- 112 Department of Anaesthesia, Critical Care & Pain Medicine NHS Lothian & University of Edinburg, Edinburgh, UK.
- 113 MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.
- 114 Department of Physical Medicine and Rehabilitation, Oslo University Hospital/University of Oslo, Oslo, Norway.
- 115 Division of Orthopedics, Oslo University Hospital, Oslo, Norway.
- 116 Institue of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
- 117 Broad Institute, Cambridge MA Harvard Medical School, Boston MA, Massachusetts General Hospital, Boston, MA, USA.
- 118 National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
- 119 Department of Neurosurgery, Odense University Hospital, Odense, Denmark.
- 120 International Neurotrauma Research Organisation, Vienna, Austria.
- 121 Klinik für Neurochirurgie, Klinikum Ludwigsburg, Ludwigsburg, Germany.
- 122 Division of Biostatistics and Epidemiology, Department of Preventive Medicine, University of Debrecen, Debrecen, Hungary.
- 123 Department Health and Prevention, University Greifswald, Greifswald, Germany.
- 124 Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Salzburg, Austria.
- 125 Department of Neurology, Elisabeth-TweeSteden Ziekenhuis, Tilburg, the Netherlands.
- 126 Department of Neuroanesthesia and Neurointensive Care, Odense University Hospital, Odense, Denmark.
- 127 Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
- 128 Department of Physical Medicine and Rehabilitation, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
- 129 Department of Neurosurgery, University of Pécs, Pécs, Hungary.
- 130 Division of Neuroscience Critical Care, John Hopkins University School of Medicine, Baltimore, USA.
- 131 Department of Neuropathology, Queen Elizabeth University Hospital and University of Glasgow, Glasgow, UK.
- 132 Dept. of Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
- 133 Department of Pathophysiology and Transplantation, Milan University, and Neuroscience ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
- 134 Department of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden.
- 135 Cochrane Consumers and Communication Review Group, Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University, Melbourne, Australia.
- 136 Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, Turku, Finland.
- 137 Department of Neurosurgery, Kaunas University of Health Sciences, Kaunas, Lithuania.
- 138 Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
- 139 Department of Intensive Care and Department of Ethics and Philosophy of Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
- 140 Department of Neurosurgery, Kings College London, London, UK.
- 141 Neurologie, Neurochirurgie und Psychiatrie, Charité - Universitätsmedizin Berlin, Berlin, Germany.
- 142 Department of Intensive Care Adults, Erasmus MC- University Medical Center Rotterdam, Rotterdam, the Netherlands.
- 143 IcoMetrix NV, Leuven, Belgium.
- 144 Department of Psychology, Antwerp University Hospital, Edegem, Belgium.
- 145 Director of Neurocritical Care, University of California, Los Angeles, USA.
- 146 Department of Neurosurgery, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
- 147 Department of Emergency Medicine, University of Florida, Gainesville, FL, USA.
- 148 Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, And Berlin Institute of Health, Berlin, Germany.
- 149 VTT Technical Research Centre, Tampere, Finland.
- 150 Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
- PMID: 36248103
- PMCID: PMC9560676
- DOI: 10.1016/j.bas.2021.100854
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Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury
Dominique L G Van Praag et al.
Brain Spine.
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Format
doi: 10.1016/j.bas.2021.100854.
eCollection 2022.
Authors
Collaborators
-
CENTER-TBI investigators and participants:
Cecilia Åkerlund 7 , Krisztina Amrein 8 , Nada Andelic 9 , Lasse Andreassen 10 , Audny Anke 11 , Anna Antoni 12 , Gérard Audibert 13 , Philippe Azouvi 14 , Maria Luisa Azzolini 15 , Ronald Bartels 16 , Pál Barzó 17 , Romuald Beauvais 18 , Ronny Beer 19 , Bo-Michael Bellander 20 , Antonio Belli 21 , Habib Benali 22 , Maurizio Berardino 23 , Luigi Beretta 15 , Morten Blaabjerg 24 , Peter Bragge 25 , Alexandra Brazinova 26 , Vibeke Brinck 27 , Joanne Brooker 28 , Camilla Brorsson 29 , Andras Buki 30 , Monika Bullinger 31 , Manuel Cabeleira 32 , Alessio Caccioppola 33 , Emiliana Calappi 33 , Maria Rosa Calvi 15 , Peter Cameron 34 , Guillermo Carbayo Lozano 35 , Marco Carbonara 33 , Simona Cavallo 23 , Giorgio Chevallard 36 , Arturo Chieregato 36 , Giuseppe Citerio 37 38 , Iris Ceyisakar 39 , Hans Clusmann 40 , Mark Coburn 41 , Jonathan Coles 42 , Jamie D Cooper 34 , Marta Correia 43 , Amra Čović 44 , Nicola Curry 45 , Endre Czeiter 30 , Marek Czosnyka 32 , Claire Dahyot-Fizelier 46 , Paul Dark 47 , Helen Dawes 48 , Véronique De Keyser 49 , Vincent Degos 22 , Francesco Della Corte 50 , Hugo den Boogert 16 , Bart Depreitere 51 , Đula Đilvesi 52 , Abhishek Dixit 53 , Emma Donoghue 28 , Jens Dreier 54 , Guy-Loup Dulière 55 , Ari Ercole 53 , Patrick Esser 48 , Erzsébet Ezer 56 , Martin Fabricius 57 , Valery L Feigin 58 , Kelly Foks 59 , Shirin Frisvold 60 , Alex Furmanov 61 , Pablo Gagliardo 62 , Damien Galanaud 22 , Dashiell Gantner 63 , Guoyi Gao 64 , Pradeep George 65 , Alexandre Ghuysen 66 , Lelde Giga 67 , Ben Glocker 68 , Jagoš Golubovic 52 , Pedro A Gomez 69 , Johannes Gratz 70 , Benjamin Gravesteijn 39 , Francesca Grossi 50 , Russell L Gruen 71 , Deepak Gupta 72 , Juanita A Haagsma 39 , Iain Haitsma 73 , Raimund Helbok 19 , Eirik Helseth 74 , Lindsay Horton 75 , Jilske Huijben 39 , Peter J Hutchinson 76 , Bram Jacobs 77 , Stefan Jankowski 78 , Mike Jarrett 27 , Ji-Yao Jiang 64 , Faye Johnson 79 , Kelly Jones 58 , Mladen Karan 52 , Angelos G Kolias 76 , Erwin Kompanje 77 , Daniel Kondziella 57 , Evgenios Koraropoulos 53 , Lars-Owe Koskinen 80 , Noémi Kovács 81 , Ana Kowark 41 , Alfonso Lagares 69 , Linda Lanyon 65 , Steven Laureys 82 , Fiona Lecky 83 84 , Didier Ledoux 82 , Rolf Lefering 85 , Valerie Legrand 86 , Aurelie Lejeune 87 , Leon Levi 88 , Roger Lightfoot 89 , Hester Lingsma 39 , Andrew Ir Maas 49 , Ana M Castaño-León 69 , Marc Maegele 90 , Marek Majdan 26 , Alex Manara 91 , Geoffrey Manley 92 , Costanza Martino 93 , Hugues Maréchal 55 , Julia Mattern 94 , Catherine McMahon 95 , Béla Melegh 96 , David Menon 53 , Tomas Menovsky 49 , Ana Mikolic 39 , Benoit Misset 82 , Visakh Muraleedharan 65 , Lynnette Murray 63 , Ancuta Negru 97 , David Nelson 7 , Virginia Newcombe 53 , Daan Nieboer 39 , József Nyirádi 8 , Otesile Olubukola 83 , Matej Oresic 98 , Fabrizio Ortolano 33 , Aarno Palotie 99 100 101 , Paul M Parizel 102 , Jean-François Payen 103 , Natascha Perera 18 , Vincent Perlbarg 22 , Paolo Persona 104 , Wilco Peul 105 , Anna Piippo-Karjalainen 106 , Matti Pirinen 99 , Horia Ples 97 , Suzanne Polinder 39 , Inigo Pomposo 35 , Jussi P Posti 107 , Louis Puybasset 108 , Andreea Radoi 109 , Arminas Ragauskas 110 , Rahul Raj 106 , Malinka Rambadagalla 111 , Jonathan Rhodes 112 , Sylvia Richardson 113 , Sophie Richter 53 , Samuli Ripatti 99 , Saulius Rocka 110 , Cecilie Roe 114 , Olav Roise 115 116 , Jonathan Rosand 117 , Jeffrey V Rosenfeld 118 , Christina Rosenlund 119 , Guy Rosenthal 61 , Rolf Rossaint 41 , Sandra Rossi 104 , Daniel Rueckert 68 , Martin Rusnák 120 , Juan Sahuquillo 109 , Oliver Sakowitz 94 121 , Renan Sanchez-Porras 121 , Janos Sandor 122 , Nadine Schäfer 85 , Silke Schmidt 123 , Herbert Schoechl 124 , Guus Schoonman 125 , Rico Frederik Schou 126 , Elisabeth Schwendenwein 12 , Charlie Sewalt 39 , Toril Skandsen 127 128 , Peter Smielewski 32 , Abayomi Sorinola 129 , Emmanuel Stamatakis 53 , Simon Stanworth 45 , Robert Stevens 130 , William Stewart 131 , Ewout W Steyerberg 39 132 , Nino Stocchetti 133 , Nina Sundström 134 , Anneliese Synnot 28 135 , Riikka Takala 136 , Viktória Tamás 129 , Tomas Tamosuitis 137 , Mark Steven Taylor 26 , Braden Te Ao 58 , Olli Tenovuo 107 , Alice Theadom 58 , Matt Thomas 91 , Dick Tibboel 138 , Marjolein Timmers 139 , Christos Tolias 140 , Tony Trapani 63 , Cristina Maria Tudora 97 , Andreas Unterberg 94 , Peter Vajkoczy 141 , Shirley Vallance 63 , Egils Valeinis 67 , Zoltán Vámos 56 , Mathieu van der Jagt 142 , Gregory Van der Steen 49 , Joukje van der Naalt 77 , Jeroen Tjm van Dijck 105 , Thomas A van Essen 105 , Wim Van Hecke 143 , Caroline van Heugten 48 , Dominique Van Praag 144 , Thijs Vande Vyvere 143 , Roel Pj van Wijk 105 , Alessia Vargiolu 38 , Emmanuel Vega 87 , Kimberley Velt 39 , Jan Verheyden 143 , Paul M Vespa 145 , Anne Vik 127 146 , Rimantas Vilcinis 137 , Victor Volovici 73 , Nicole von Steinbüchel 44 , Daphne Voormolen 39 , Petar Vulekovic 52 , Kevin Kw Wang 147 , Eveline Wiegers 39 , Guy Williams 53 , Lindsay Wilson 75 , Stefan Winzeck 53 , Stefan Wolf 148 , Zhihui Yang 147 , Peter Ylén 149 , Alexander Younsi 94 , Frederick A Zeiler 53 150 , Veronika Zelinkova 26 , Agate Ziverte 67 , Tommaso Zoerle 33
Affiliations
- 1 Department of Psychology, Antwerp University Hospital, Edegem and University of Antwerp, Antwerp, Belgium.
- 2 Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Drie Eikenstraat 655, 2650, Edegem, Belgium.
- 3 Clinical Trial Centre (CTC), CRC Antwerp, Antwerp University Hospital, Edegem and University of Antwerp, Antwerp, Belgium.
- 4 Department of Psychiatry, Antwerp University Hospital, Drie Eikenstraat 655, 2650, Edegem, Belgium.
- 5 Division of Psychology, University of Stirling, Stirling, FK9 4LA, United Kingdom.
- 6 Department of Neurosurgery, Antwerp University Hospital, Edegem and University of Antwerp, Drie Eikenstraat 655, 2650, Edegem, Belgium.
- 7 Department of Physiology and Pharmacology, Section of Perioperative Medicine and Intensive Care, Karolinska Institutet, Stockholm, Sweden.
- 8 János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
- 9 Division of Surgery and Clinical Neuroscience, Department of Physical Medicine and Rehabilitation, Oslo University Hospital and University of Oslo, Oslo, Norway.
- 10 Department of Neurosurgery, University Hospital Northern Norway, Tromso, Norway.
- 11 Department of Physical Medicine and Rehabilitation, University Hospital Northern Norway, Tromso, Norway.
- 12 Trauma Surgery, Medical University Vienna, Vienna, Austria.
- 13 Department of Anesthesiology & Intensive Care, University Hospital Nancy, Nancy, France.
- 14 Raymond Poincare Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.
- 15 Department of Anesthesiology & Intensive Care, S Raffaele University Hospital, Milan, Italy.
- 16 Department of Neurosurgery, Radboud University Medical Center, Nijmegen, the Netherlands.
- 17 Department of Neurosurgery, University of Szeged, Szeged, Hungary.
- 18 International Projects Management, ARTTIC, Munchen, Germany.
- 19 Department of Neurology, Neurological Intensive Care Unit, Medical University of Innsbruck, Innsbruck, Austria.
- 20 Department of Neurosurgery & Anesthesia & Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden.
- 21 NIHR Surgical Reconstruction and Microbiology Research Centre, Birmingham, UK.
- 22 Anesthesie-Réanimation, Assistance Publique - Hopitaux de Paris, Paris, France.
- 23 Department of Anesthesia & ICU, AOU Città della Salute e della Scienza di Torino - Orthopedic and Trauma Center, Torino, Italy.
- 24 Department of Neurology, Odense University Hospital, Odense, Denmark.
- 25 BehaviourWorks Australia, Monash Sustainability Institute, Monash University, Victoria, Australia.
- 26 Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovakia.
- 27 Quesgen Systems Inc., Burlingame, CA, USA.
- 28 Australian & New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
- 29 Department of Surgery and Perioperative Science, Umeå University, Umeå, Sweden.
- 30 Department of Neurosurgery, Medical School, University of Pécs, Hungary and Neurotrauma Research Group, János Szentágothai Research Centre, University of Pécs, Hungary.
- 31 Department of Medical Psychology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
- 32 Brain Physics Lab, Division of Neurosurgery, Dept of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
- 33 Neuro ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
- 34 School of Public Health & PM, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia.
- 35 Department of Neurosurgery, Hospital of Cruces, Bilbao, Spain.
- 36 NeuroIntensive Care, Niguarda Hospital, Milan, Italy.
- 37 School of Medicine and Surgery, Università Milano Bicocca, Milano, Italy.
- 38 NeuroIntensive Care, ASST di Monza, Monza, Italy.
- 39 Department of Public Health, Erasmus Medical Center-University Medical Center, Rotterdam, the Netherlands.
- 40 Department of Neurosurgery, Medical Faculty RWTH Aachen University, Aachen, Germany.
- 41 Department of Anaesthesiology, University Hospital of Aachen, Aachen, Germany.
- 42 Department of Anesthesia & Neurointensive Care, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.
- 43 Radiology/MRI department, MRC Cognition and Brain Sciences Unit, Cambridge, UK.
- 44 Institute of Medical Psychology and Medical Sociology, Universitätsmedizin Göttingen, Göttingen, Germany.
- 45 Oxford University Hospitals NHS Trust, Oxford, UK.
- 46 Intensive Care Unit, CHU Poitiers, Potiers, France.
- 47 University of Manchester NIHR Biomedical Research Centre, Critical Care Directorate, Salford Royal Hospital NHS Foundation Trust, Salford, UK.
- 48 Movement Science Group, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
- 49 Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium.
- 50 Department of Anesthesia & Intensive Care, Maggiore Della Carità Hospital, Novara, Italy.
- 51 Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.
- 52 Department of Neurosurgery, Clinical Centre of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
- 53 Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
- 54 Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, And Berlin Institute of Health, Berlin, Germany.
- 55 Intensive Care Unit, CHR Citadelle, Liège, Belgium.
- 56 Department of Anaesthesiology and Intensive Therapy, University of Pécs, Pécs, Hungary.
- 57 Departments of Neurology, Clinical Neurophysiology and Neuroanesthesiology, Region Hovedstaden Rigshospitalet, Copenhagen, Denmark.
- 58 National Institute for Stroke and Applied Neurosciences, Faculty of Health and Environmental Studies, Auckland University of Technology, Auckland, New Zealand.
- 59 Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
- 60 Department of Anesthesiology and Intensive Care, University Hospital Northern Norway, Tromso, Norway.
- 61 Department of Neurosurgery, Hadassah-hebrew University Medical Center, Jerusalem, Israel.
- 62 Fundación Instituto Valenciano de Neurorrehabilitación (FIVAN), Valencia, Spain.
- 63 ANZIC Research Centre, Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Victoria, Australia.
- 64 Department of Neurosurgery, Shanghai Renji Hospital, Shanghai Jiaotong University/school of Medicine, Shanghai, China.
- 65 Karolinska Institutet, INCF International Neuroinformatics Coordinating Facility, Stockholm, Sweden.
- 66 Emergency Department, CHU, Liège, Belgium.
- 67 Neurosurgery Clinic, Pauls Stradins Clinical University Hospital, Riga, Latvia.
- 68 Department of Computing, Imperial College London, London, UK.
- 69 Department of Neurosurgery, Hospital Universitario 12 de Octubre, Madrid, Spain.
- 70 Department of Anesthesia, Critical Care and Pain Medicine, Medical University of Vienna, Austria.
- 71 College of Health and Medicine, Australian National University, Canberra, Australia.
- 72 Department of Neurosurgery, Neurosciences Centre & JPN Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, 110029, India.
- 73 Department of Neurosurgery, Erasmus MC, Rotterdam, the Netherlands.
- 74 Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.
- 75 Division of Psychology, University of Stirling, Stirling, UK.
- 76 Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital & University of Cambridge, Cambridge, UK.
- 77 Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 78 Neurointensive Care, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
- 79 Salford Royal Hospital NHS Foundation Trust Acute Research Delivery Team, Salford, UK.
- 80 Department of Clinical Neuroscience, Neurosurgery, Umeå University, Umeå, Sweden.
- 81 Hungarian Brain Research Program - Grant No. KTIA_13_NAP-A-II/8, University of Pécs, Pécs, Hungary.
- 82 Cyclotron Research Center, University of Liège, Liège, Belgium.
- 83 Centre for Urgent and Emergency Care Research (CURE), Health Services Research Section, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
- 84 Emergency Department, Salford Royal Hospital, Salford, UK.
- 85 Institute of Research in Operative Medicine (IFOM), Witten/Herdecke University, Cologne, Germany.
- 86 VP Global Project Management CNS, ICON, Paris, France.
- 87 Department of Anesthesiology-Intensive Care, Lille University Hospital, Lille, France.
- 88 Department of Neurosurgery, Rambam Medical Center, Haifa, Israel.
- 89 Department of Anesthesiology & Intensive Care, University Hospitals Southhampton NHS Trust, Southhampton, UK.
- 90 Cologne-Merheim Medical Center (CMMC), Department of Traumatology, Orthopedic Surgery and Sportmedicine, Witten/Herdecke University, Cologne, Germany.
- 91 Intensive Care Unit, Southmead Hospital, Bristol, Bristol, UK.
- 92 Department of Neurological Surgery, University of California, San Francisco, CA, USA.
- 93 Department of Anesthesia & Intensive Care,M. Bufalini Hospital, Cesena, Italy.
- 94 Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
- 95 Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.
- 96 Department of Medical Genetics, University of Pécs, Pécs, Hungary.
- 97 Department of Neurosurgery, Emergency County Hospital Timisoara, Timisoara, Romania.
- 98 School of Medical Sciences, Örebro University, Örebro, Sweden.
- 99 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
- 100 Analytic and Translational Genetics Unit, Department of Medicine, Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
- 101 Program in Medical and Population Genetics, The Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 102 Department of Radiology, University of Antwerp, Edegem, Belgium.
- 103 Department of Anesthesiology & Intensive Care, University Hospital of Grenoble, Grenoble, France.
- 104 Department of Anesthesia & Intensive Care, Azienda Ospedaliera Università di Padova, Padova, Italy.
- 105 Dept. of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands and Dept. of Neurosurgery, Medical Center Haaglanden, The Hague, the Netherlands.
- 106 Department of Neurosurgery, Helsinki University Central Hospital, Finland.
- 107 Division of Clinical Neurosciences, Department of Neurosurgery and Turku Brain Injury Centre, Turku University Hospital and University of Turku, Turku, Finland.
- 108 Department of Anesthesiology and Critical Care, Pitié -Salpêtrière Teaching Hospital, Assistance Publique, Hôpitaux de Paris and University Pierre et Marie Curie, Paris, France.
- 109 Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d'Hebron Research Institute, Barcelona, Spain.
- 110 Department of Neurosurgery, Kaunas University of Technology and Vilnius University, Vilnius, Lithuania.
- 111 Department of Neurosurgery, Rezekne Hospital, Latvia.
- 112 Department of Anaesthesia, Critical Care & Pain Medicine NHS Lothian & University of Edinburg, Edinburgh, UK.
- 113 MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.
- 114 Department of Physical Medicine and Rehabilitation, Oslo University Hospital/University of Oslo, Oslo, Norway.
- 115 Division of Orthopedics, Oslo University Hospital, Oslo, Norway.
- 116 Institue of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
- 117 Broad Institute, Cambridge MA Harvard Medical School, Boston MA, Massachusetts General Hospital, Boston, MA, USA.
- 118 National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
- 119 Department of Neurosurgery, Odense University Hospital, Odense, Denmark.
- 120 International Neurotrauma Research Organisation, Vienna, Austria.
- 121 Klinik für Neurochirurgie, Klinikum Ludwigsburg, Ludwigsburg, Germany.
- 122 Division of Biostatistics and Epidemiology, Department of Preventive Medicine, University of Debrecen, Debrecen, Hungary.
- 123 Department Health and Prevention, University Greifswald, Greifswald, Germany.
- 124 Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Salzburg, Austria.
- 125 Department of Neurology, Elisabeth-TweeSteden Ziekenhuis, Tilburg, the Netherlands.
- 126 Department of Neuroanesthesia and Neurointensive Care, Odense University Hospital, Odense, Denmark.
- 127 Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
- 128 Department of Physical Medicine and Rehabilitation, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
- 129 Department of Neurosurgery, University of Pécs, Pécs, Hungary.
- 130 Division of Neuroscience Critical Care, John Hopkins University School of Medicine, Baltimore, USA.
- 131 Department of Neuropathology, Queen Elizabeth University Hospital and University of Glasgow, Glasgow, UK.
- 132 Dept. of Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
- 133 Department of Pathophysiology and Transplantation, Milan University, and Neuroscience ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
- 134 Department of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden.
- 135 Cochrane Consumers and Communication Review Group, Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University, Melbourne, Australia.
- 136 Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, Turku, Finland.
- 137 Department of Neurosurgery, Kaunas University of Health Sciences, Kaunas, Lithuania.
- 138 Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
- 139 Department of Intensive Care and Department of Ethics and Philosophy of Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
- 140 Department of Neurosurgery, Kings College London, London, UK.
- 141 Neurologie, Neurochirurgie und Psychiatrie, Charité - Universitätsmedizin Berlin, Berlin, Germany.
- 142 Department of Intensive Care Adults, Erasmus MC- University Medical Center Rotterdam, Rotterdam, the Netherlands.
- 143 IcoMetrix NV, Leuven, Belgium.
- 144 Department of Psychology, Antwerp University Hospital, Edegem, Belgium.
- 145 Director of Neurocritical Care, University of California, Los Angeles, USA.
- 146 Department of Neurosurgery, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
- 147 Department of Emergency Medicine, University of Florida, Gainesville, FL, USA.
- 148 Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, And Berlin Institute of Health, Berlin, Germany.
- 149 VTT Technical Research Centre, Tampere, Finland.
- 150 Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
- PMID: 36248103
- PMCID: PMC9560676
- DOI: 10.1016/j.bas.2021.100854
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Abstract
Introduction: Neurocognitive problems associated with posttraumatic stress disorder (PTSD) can interact with impairment resulting from traumatic brain injury (TBI).
Research question: We aimed to identify neurocognitive problems associated with probable PTSD following TBI in a civilian sample.
Material and methods: The study is part of the CENTER-TBI project (Collaborative European Neurotrauma Effectiveness Research) that aims to better characterize TBI. For this cross-sectional study, we included patients of all severities aged over 15, and a Glasgow Outcome Score Extended (GOSE) above 3. Participants were assessed at six months post-injury on the PTSD Checklist-5 (PCL-5), the Trail Making Test (TMT), the Rey Auditory Verbal Learning Test (RAVLT) and the Cambridge Neuropsychological Test Automated Battery (CANTAB). Primary analysis was a complete case analysis. Regression analyses were performed to investigate the association between the PCL-5 and cognition.
Results: Of the 1134 participants included in the complete case analysis, 13.5% screened positive for PTSD. Probable PTSD was significantly associated with higher TMT-(B-A) (OR = 1.35, 95% CI: 1.14-1.60, p < .001) and lower RAVLT-delayed recall scores (OR = 0.74, 95% CI: 0.61-0.91, p = .004) after controlling for age, sex, psychiatric history, baseline Glasgow Coma Scale and education.
Discussion and conclusion: Poorer performance on cognitive tests assessing task switching and, to a lesser extent, delayed verbal recall is associated with probable PTSD in civilians who have suffered TBI.
Keywords: Cognition; Head injury; Neuropsychology; Posttraumatic stress disorder; Stress.
© 2021 The Authors.
Conflict of interest statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Figures
Fig. 1
Flowchart of patient inclusion and…
Fig. 1
Flowchart of patient inclusion and exclusion.
Flowchart of patient inclusion and exclusion.
Fig. 1
Probable PTSD diagnosis differentiated for…
Fig. 1
Probable PTSD diagnosis differentiated for GCS rating.
Probable PTSD diagnosis differentiated for GCS rating.
Fig. 2
Probable PTSD diagnosis differentiated for…
Fig. 2
Probable PTSD diagnosis differentiated for GOSE rating Note: GOSE 4: Upper Severe Disability…
Probable PTSD diagnosis differentiated for GOSE rating Note: GOSE 4: Upper Severe Disability – needs full assistance in activities of daily living, GOSE 5: Lower Moderate Disability – independent, but cannot resume work/school or all previous social activities, GOSE 6: Upper Moderate Disability – Some disability exists, but can partly resume work or previous activities, GOSE 7: Lower Good Recovery – Minor physical or mental deficits that affects daily life, GOSE 8: Upper Good Recovery – Full recovery or minor symptoms that do not affect daily life
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