Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Sep 29:12:989896.
doi: 10.3389/fonc.2022.989896. eCollection 2022.

Ferroptosis in glioma treatment: Current situation, prospects and drug applications

Yuhang Zhou  1   2 , Chaoyou Fang  3 , Houshi Xu  3 , Ling Yuan  3 , Yibo Liu  4 , Xiaoyu Wang  4 , Anke Zhang  4 , Anwen Shao  4 , Danyang Zhou  1
Affiliations

Ferroptosis in glioma treatment: Current situation, prospects and drug applications

Yuhang Zhou et al. Front Oncol. .

Abstract

Ferroptosis is a regulatory form of iron-dependent cell death caused by the accumulation of lipid-based reactive oxygen species (ROS) and differs from apoptosis, pyroptosis, and necrosis. Especially in neoplastic diseases, the susceptibility of tumor cells to ferroptosis affects prognosis and is associated with complex effects. Gliomas are the most common primary intracranial tumors, accounting for disease in 81% of patients with malignant brain tumors. An increasing number of studies have revealed the particular characteristics of iron metabolism in glioma cells. Therefore, agents that target a wide range of molecules involved in ferroptosis may regulate this process and enhance glioma treatment. Here, we review the underlying mechanisms of ferroptosis and summarize the potential therapeutic options for targeting ferroptosis in glioma.

Keywords: ferroptosis; glioma; iron metabolism; reactive oxygen species; targeting treatment.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The overview of ferroptosis pathways. (A): the iron metabolism pathway; (B): the lipid peroxidation pathway; (C): the antioxidant systems pathway; (D): the GPX4-mediated pathway. The green line means the substance acts across pathways.
See this image and copyright information in PMC

References

    1. Ma Q, Long W, Xing C, Chu J, Luo M, Wang HY, et al. . Cancer stem cells and immunosuppressive microenvironment in glioma. Front Immunol (2018) 9:2924. doi: 10.3389/fimmu.2018.02924 - DOI - PMC - PubMed
    1. Walid MS, Smisson HF3, Robinson JS Jr. Long-term survival after glioblastoma multiforme. South Med J (2008) 101(9):971–2. doi: 10.1097/SMJ.0b013e31818005e5 - DOI - PubMed
    1. Minniti G, Niyazi M, Alongi F, Navarria P, Belka C. Current status and recent advances in reirradiation of glioblastoma. Radiat Oncol (London England) (2021) 16(1):36. doi: 10.1186/s13014-021-01767-9 - DOI - PMC - PubMed
    1. Kelly PJ, Daumas-Duport C, Kispert DB, Kall BA, Scheithauer BW, Illig JJ. Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms. J Neurosurg (1987) 66(6):865–74. doi: 10.3171/jns.1987.66.6.0865 - DOI - PubMed
    1. Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, et al. . ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis. contributing to TMZ resistance glioma Theranostics (2020) 10(7):3351–65. doi: 10.7150/thno.41219 - DOI - PMC - PubMed

Publication types

LinkOut - more resources