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Review
. 2022 Sep 28:12:1011230.
doi: 10.3389/fonc.2022.1011230. eCollection 2022.

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis

Lei Sang  1   2 , Xingshun Wang  1   2 , Weiyu Bai  2 , Junling Shen  2 , Yong Zeng  1   3 , Jianwei Sun  2
Affiliations
Review

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis

Lei Sang et al. Front Oncol. .

Abstract

Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and diabetes mellitus. Recently, HNF4α has been emerging as a key player in a variety of cancers. In this review, we summarized the role and mechanism of HNF4α in different types of cancers, especially in liver and colorectal cancer, aiming to provide additional guidance for intervention of these diseases.

Keywords: HNF4α; colorectal cancer; liver cancer; transcription factor; tumorigenesis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
HNF4α expression levels in different types of cancer tissues and their matched normal counterparts. *indicates p<0.05. The raw data are from http://gepia2.cancer-pku.cn.
See this image and copyright information in PMC

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