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Case Reports
. 2022 Sep 27;17(1):1309-1314.
doi: 10.1515/biol-2022-0473. eCollection 2022.

One case of iodine-125 therapy - A new minimally invasive treatment of intrahepatic cholangiocarcinoma

Xinju Chen  1 , Xiaoqi Chen  1 , Chuanlei Zhang  1 , Xinting Wang  1 , Changwei Yuan  1 , He Yang  1 , Lixia Yang  1
Affiliations
Case Reports

One case of iodine-125 therapy - A new minimally invasive treatment of intrahepatic cholangiocarcinoma

Xinju Chen et al. Open Life Sci. .

Abstract

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer associated with a poor prognosis. ICC accounts for about 10% of primary liver malignancies but with increasing incidence in recent years. Recently, some studies suggested that minimally interventional therapy can be used in the treatment of ICC. However, there are few references on interventional therapy for the clinical treatment of ICC. Herein we reported a case of a 48-year-old man who suffered from ICC. The patient was diagnosed with ICC by computerized tomography scan and pathological biopsy. The patient was completely cured by minimally interventional therapy with iodine-125 seed implantation. These results provide an important reference for the treatment option of ICC.

Keywords: intrahepatic cholangiocarcinoma; iodine-125; transcatheter arterial chemoembolization.

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Conflict of interest statement

Conflict of interest: Authors state no conflict of interest.

Figures

Figure 1
Figure 1
CT-scan showing the size of lesion. The arrow points to a lesion of 5.5 cm × 5.1 cm.
Figure 2
Figure 2
CT-scan showing a little iodized oil deposition shadows.
Figure 3
Figure 3
The pistol type particle implantation device.
Figure 4
Figure 4
Iodine-125 seed implantation around the lesion in a fan shape with a distance of 1 cm between each two seeds with CT guidance.
Figure 5
Figure 5
CT-scan showing that lesions were completely necrotic and no signs of recurrence after 3 months of treatment.
Figure 6
Figure 6
CT-scan showing that lesions were completely necrotic and no signs of recurrence after 5 years of treatment.
See this image and copyright information in PMC

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References

    1. Sirica AE, Strazzabosco M, Cadamuro M. Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression. Adv Cancer Res. 2021;149:321–87. - PMC - PubMed
    1. Mandrekar P, Cardinale V. Periostin and mesothelin: Potential predictors of malignant progression in intrahepatic cholangiocarcinoma. Hepatol Commun. 2018;2(5):481–3. - PMC - PubMed
    1. Spratt B, Kozan E, Sinnott M. Analysis of uncertainty in the surgical department: Durations, requests and cancellations. Aust Health Rev. 2019;43(6):706–11. - PubMed
    1. Seidensticker R, Seidensticker M, Doegen K, Mohnike K, Schütte K, Stübs P, et al. Extensive use of interventional therapies improves survival in unresectable or recurrent intrahepatic cholangiocarcinoma. Gastroenterol Res Pract. 2016;2016:8732521. - PMC - PubMed
    1. Ierardi AM, Angileri SA, Patella F, Panella S, Lucchina N, Petre EN, et al. The role of interventional radiology in the treatment of intrahepatic cholangiocarcinoma. Med Oncol. 2017;34(1):11. - PubMed

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